趋化因子CXC亚家族受体4在食管鳞癌组织中表达情况及预后价值分析  

Analysis of expression and prognostic value of CXC subfamily receptor 4 in esophageal squamous cell carcinoma

作　　者：朱文强 黄杰 蔡彭 赵红雨 时雪玲 韩秀美 李多杰[1] ZHU Wenqiang;HUANG Jie;CAI Peng;ZHAO Hongyu;SHI Xueling;HAN Xiumei;LI Duojie(Department of Radiation Oncology,the First Affiliated Hospital of Bengbu Medical College,Anhui Province,Bengbu233000,China)

机构地区：[1]蚌埠医学院第一附属医院放射肿瘤科,安徽蚌埠233000

出　　处：《中国医药导报》2024年第8期13-17,共5页China Medical Herald

基　　金：安徽省教育厅自然科学基金资助项目(KJ2021A0699)。

摘　　要：目的 探索趋化因子CXC亚家族受体4(CXCR4)在食管鳞癌(ESCC)组织中的表达情况及其与ESCC患者临床病理特征和预后的相关性。方法 本研究为回顾性队列研究,抽取蚌埠医学院第一附属医院2018年1月至12月行食管癌根治术的ESCC患者术后切片共107例作为研究组,选取其中21例患者的癌旁组织作为对照组。采用免疫组织化学染色测定两组CXCR4表达情况,分析107例ESCC患者的临床病历资料,研究CXCR4表达情况与患者临床病理特征和预后的关系。结果 研究组CXCR4阳性表达率高于对照组,差异有统计学意义(P<0.05)。不同年龄、分化程度、侵犯深度、淋巴结转移情况ESCC患者癌组织中CXCR4表达水平比较,差异有统计学意义(P<0.05)。Kaplan-Meier生存曲线分析显示,CXCR4阳性表达患者总生存期及无病生存期低于阴性表达患者,差异有统计学意义(P<0.05)。Cox回归模型分析显示,肿瘤侵犯深度、分化程度、淋巴结转移情况及CXCR4表达水平是ESCC患者总生存期、无病生存期的独立影响因素(P<0.05)。结论 ESCC患者癌组织中CXCR4阳性表达率升高,CXCR4高表达可能促进ESCC对食管的侵犯及淋巴结转移。CXCR4在ESCC中的高表达可能与患者预后较差有关。Objective To explore the expression of CXC subfamily receptor 4(CXCR4)in esophageal squamous cell carcinoma(ESCC)and its correlation with clinicopathological features and prognosis of ESCC patients.Methods This study was a retrospective cohort study.A total of 107 ESCC patients underwent radical esophagectomy for esophageal cancer in the First Affiliated Hospital of Bengbu Medical College from January to December 2018 were selected as the study group,and the adjacent tissues of 21 patients among them were selected as the control group.The expression of CXCR4 in the two groups was determined by immunohistochemical stain,and the clinical medical records of 107 ESCC patients were analyzed to study the relationship between CXCR4 expression and clinicopathological features and prognosis of the patients.Results The positive expression rate of CXCR4 in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).There were statistically significant differences in CXCR4 expression levels in cancer tissues of ESCC patients with different ages,degrees of differentiation,depth of invasion,and lymph node metastasis(P<0.05).Kaplan-Meier survival curve analysis showed that the overall survival and disease-free survival of patients with CXCR4 positive expression were lower than those with negative expression,and the differences were statistically significant(P<0.05).Cox regression model analysis showed that the depth of tumor invasion,degree of differentiation,lymph node metastasis,and CXCR4 expression level were independent influencing factors for overall survival and disease-free survival in ESCC patients(P<0.05).Conclusion The positive expression rate of CXCR4 in cancer tissues of ESCC patients increased,and the high expression of CXCR4 may promote ESCC invasion of esophagus and lymph node metastasis.The high expression of CXCR4 in ESCC may be associated with poor patient outcomes.

关 键 词：食管鳞癌 趋化因子CXC亚家族受体4 淋巴结转移 预后 

分 类 号：R735.1[医药卫生—肿瘤]