A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients  

作　　者：Zhe Zhang Wenjing Yang Zhengshan Chen Haoang Chi Shipo Wu Wanru Zheng Ruochun Jin Busen Wang Yudong Wang Nan Huo Jinlong Zhang Xiaohong Song Liyang Xu Jun Zhang Lihua Hou Wei Chen 

机构地区：[1]Institute of Biotechnology,Academy of Military Medical Sciences,Beijing 100071,China [2]Department of Intelligent Data Science,College of Computer Science and Technology,National University of Defense Technology,Changsha 410073,China [3]Intelligent Game and Decision Lab,Academy of Military Science,Beijing 100091,China

出　　处：《The Innovation》2024年第3期77-87,共11页创新（英文）

基　　金：National Natural Science Foundation of China 31900671.

摘　　要：The vaccine-induced innate immune response is essential for the generation of an antibody response.To date,how Ad5-vectored vaccines are influenced by preexisting anti-Ad5 antibodies during activation of the early immune response remains unclear.Here,we investigated the specific alterations in GP1,2-specific IgG-related elements of the early immune response at the genetic,molecular,and cellular levels on days 0,1,3,and 7 after Ad5-EBOV vaccination.In a causal multiomics analysis,distinct early immune responses associated with GP1,2-specific IgG were observed in Ad5-EBOV recipients with a low level of preexisting anti-Ad5 antibodies.This study revealed the correlates of the Ad5-EBOV-induced IgG response and provided mechanistic evidence for overcoming preexisting Ad5 immunity during the administration of Ad5-vectored vaccines.

关 键 词：VACCINE immunity alterations 

分 类 号：R186[医药卫生—流行病学]