观察氟伏沙明片联合小剂量米氮平片治疗抑郁症伴失眠的临床效果  

Observation of the Clinical Efficacy of Fluvoxamine Tablets Combined with Low-dose Mirtazapine Tablets in the Treatment of Depression with Insomnia

作　　者：林丽心 陈明钟 魏敏 LIN Lixin;CHEN Mingzhong;WEI Min(Fuzhou Neuropsychiatric Hospital,Fuzhou 350008,China)

机构地区：[1]福州神经精神病防治院,福州350008

出　　处：《世界睡眠医学杂志》2024年第2期263-265,共3页World Journal of Sleep Medicine

摘　　要：目的:探究氟伏沙明片联合小剂量米氮平片在抑郁症伴失眠治疗中的意义。方法:选取2021年1月至2022年7月福州神经精神病防治院精神科收治的抑郁症伴失眠患者40例作为研究对象,按照随机数字表法分为对照组和观察组,每组20例,对照组给予氟伏沙明片治疗,观察组给予氟伏沙明片联合小剂量米氮平片治疗。采用汉密尔顿抑郁量表(HAMD)对患者负面情绪进行评价比较,根据患者的临床症状缓解情况评价2组的治疗效果,采用药物不良反应量表(TESS)比较2组患者干预前后的不良反应发生情况。结果:干预后,观察组治疗总有效率显著高于对照组,HAMD评分显著低于对照组,观察组不良反应TESS评分显著低于对照组,差异均有统计学意义(均P>0.05)。结论:在抑郁症伴失眠患者中应用氟伏沙明片联合小剂量米氮平治疗,可有效提高治疗效果,改善患者抑郁情况,且安全有效,值得临床推广应用。Objective:To explore the significance of fluvoxamine tablets combined with low-dose mirtazapine tablets in the treatment of depression with insomnia.Methods:Forty patients with depression and insomnia admitted to the psychiatric department of Fuzhou Neuropsychiatric Hospital from January 2021 to July 2022 were selected as the study subjects.They were randomly divided into an observation group(n=20)and a control group(n=20)using a random number table method.The control group was treated with fluvoxamine tablets,while the observation group was treated with fluvoxamine tablets combined with low-dose mirtazapine tablets.The Hamilton Depression Scale(HAMD)was used to evaluate and compare the negative emotions of patients,and the treatment effects of two groups were evaluated based on the clinical symptom relief of patients.The Drug Adverse Reaction Scale(TESS)was used to compare the incidence of adverse reactions before and after intervention between the two groups of patients.Results:After intervention,the total effective rate of treatment in the observation group was significantly higher than that in the control group,the HAMD score was significantly lower than that in the control group,and the TESS score for side effects in the observation group was significantly lower than that in the control group.The difference between the two groups was statistically significant(P>0.05).Conclusion:The application of fluvoxamine tablets combined with low-dose mirtazapine in the treatment of patients with depression and insomnia can effectively improve the treatment effect,improve the patient′s depression situation,and is safe and effective,which is worthy of clinical promotion and application.

关 键 词：氟伏沙明片 米氮平片 抑郁症 失眠 抑郁 

分 类 号：R749.41[医药卫生—神经病学与精神病学] R338.63[医药卫生—临床医学]