阿替普酶联合丁苯酞在超早期急性脑梗死患者溶栓治疗中的作用  

Effect of Alteplase Combined with Butylphthalein on Thrombolytic Therapy in Patients with Ultra-early Acute Cerebral Infarction

作　　者：张淑秀 张士亮[2] ZHANG Shuxiu;ZHANG Shiliang(Department of Neurology,Zaozhuang Shizhong District People's Hospital,Zaozhuang,Shandong Province,277100 China;Department of Neurology,Zaozhuang Municipal Hospital,Zaozhuang,Shandong Province,277100 China)

机构地区：[1]山东省枣庄市市中区人民医院神经内科,山东枣庄277100 [2]山东省枣庄市立医院神经内科,山东枣庄277100

出　　处：《系统医学》2024年第5期109-112,共4页Systems Medicine

摘　　要：目的分析在超早期急性脑梗死患者溶栓治疗中阿替普酶联合丁苯酞的临床效果。方法回顾性选取2020年7月—2022年6月枣庄市市中区人民医院收治的96例超早期急性脑梗死患者的临床资料,以不同治疗方式分为观察组(给予阿替普酶联合丁苯酞溶栓治疗)和对照组(给予阿替普酶静脉溶栓治疗),各48例。比较两组患者治疗有效率、神经功能及生活活动能力评分、不良反应发生率。结果治疗后,观察组治疗总有效率、生活活动能力评分高于对照组,神经功能评分低于对照组,差异有统计学意义(P均<0.05)。两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论联合溶栓治疗急性脑梗死的临床疗效良好,可有效促进神经功能及日常活动能力恢复。Objective To analyze the clinical effect of thrombolytic therapy of alteplase combined with butylphthalein in patients with ultra-early acute cerebral infarction.Methods The clinical data of 96 patients with ultra-early acute cerebral infarction admitted to Zaozhuang Shizhong District People's Hospital from July 2020 to June 2022 were retro⁃spectively selected.According to different treatment methods,they were divided into observation group(given al⁃teplase combined with butylphthalein thrombolytic therapy)and control group(given alteplase intravenous thrombo⁃lytic therapy),with 48 cases in each group.The effective rate of treatment,the scores of nerve function and activity of life,and the incidence of adverse reactions were compared between the two groups.Results After treatment,the total treatment efficiency and life activity scores of the observation group were higher than those of the control group,and the neurological function scores were lower than those of the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Combined thrombolytic therapy for acute cerebral infarction has good clinical effect and can effec⁃tively promote the recovery of nerve function and daily activity ability.

关 键 词：超早期 急性脑梗死 阿替普酶 静脉溶栓 丁苯酞 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]