细胞焦亡在肾缺血再灌注损伤中的研究进展  

Progress of research into pyroptosis in renal ischemia-reperfusion injury

作　　者：孙豪杰 朱俊雷 李伟[1,2] 王锁刚 SUN Haojie;ZHU Junlei;LI Wei;WANG Suogang(the First Ward of Urology Department,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450003,China;the First Clinical Medical College of Henan University of Traditional Chinese Medicine,Zhengzhou 450003)

机构地区：[1]河南中医药大学第一附属医院泌尿外科一区,郑州450003 [2]河南中医药大学第一临床医学院,郑州450003

出　　处：《中国比较医学杂志》2024年第3期172-178,共7页Chinese Journal of Comparative Medicine

基　　金：河南省中医药科学研究专项课题(20-21ZY2188)。

摘　　要：细胞焦亡是半胱氨酸蛋白酶介导的以线粒体参与、炎性小体组装、质膜穿孔、炎性释放为特征的细胞程序性死亡。作为介导机体炎症反应的重要机制,细胞焦亡在肾缺血再灌注损伤(renal ischemia-reperfusion injury,RIRI)中发挥了关键作用。本文就近年来细胞焦亡的分子机制、细胞焦亡在RIRI中的作用机制和治疗药物的研究进展进行综述,旨在为RIRI的早期治疗提供理论参考。Pyroptosis is a programmed cell death mediated by cysteine proteases and is characterized by mitochondrial participation,inflammasome assembly,plasma membrane perforation,and inflammatory release.As an important mechanism mediating the body’s inflammatory responses,pyroptosis plays a key role in renal ischemia-reperfusion injury(RIRI).This article reviews the molecular mechanisms of pyroptosis,pyroptotic mechanisms in RIRI,and the progress of research into therapeutic drugs in recent years,with the aim of providing a theoretical reference for the development of early treatments for RIRI.

关 键 词：肾移植 缺血-再灌注损伤 细胞焦亡 抑制剂 干预手段 

分 类 号：R-33[医药卫生]