铂耐药卵巢癌复发现状及相关因素  

Status of platinum resistant ovarian cancer recurrence and related factors

作　　者：刘建[1] 廖宗敏 胡红波[1] LIU Jian;LIAO Zong-Min;HU Hong-Bo(Department of gynaecology,Yuebei People's Hospital,Shaoguan 512026,Guangdong,China)

机构地区：[1]粤北人民医院妇科,广东韶关512026

出　　处：《吉林医学》2024年第5期1030-1033,共4页Jilin Medical Journal

基　　金：韶关市科技计划项目[项目编号:220522154531146];韶关市卫生健康科研计划项目[项目编号:Y22004]。

摘　　要：目的:分析铂耐药卵巢癌复发现状及相关因素。方法:选取粤北人民医院2013年1月~2020年1月收治的86例复发性卵巢癌患者为研究对象,分为对照组(n=66)与观察组(n=20),单因素、多因素Logistic回归分析铂耐药卵巢癌复发的危险因素。结果:Logistic回归分析:脉管癌栓、初治时腹水量≥1000 ml、腹水有癌细胞、糖类抗原125(CA125)≥200 U/ml、FIGO分期、白蛋白(ALB)≤35 g/L、淋巴细胞与单核细胞比值(LMR)<5.12、血小板与淋巴细胞比值(PLR)≥124是卵巢癌复发的危险因素,差异有统计学意义(P<0.05)。结论:铂耐药卵巢癌复发与脉管癌栓、初治时腹水量、腹水有癌细胞、FIGO分期、人附睾蛋白4(HE4)、CA125、AIB、LMR、PLR异常等因素有关,应及早给予针对性处理,最大限度降低复发率。Objective To analyze the status and related factors of platinum resistant ovarian cancer recurrence.Method A total of 86 patients with recurrent ovarian cancer admitted to our hospital were selected as research object,they were divided into control group(n=66)and observation group(n=20).Univariate and multivariate logistic regression analysis was conducted to analyze the risk factors of recurrent platinum-resistant ovarian cancer.Results Logistic regression analysis:Vascular cancer thrombus,abdominal water≥1000 ml at initial treatment,ascites with cancer cells,carbohydrate antigen 125(CA125)≥200 U/ml,FIGO staging,albumin(AIB)≤35 g/L,lymphocyte to monocyte ratio(LMR)<5.12,platelet to lymphocyte ratio(PLR)≥124 were the risk of ovarian cancer recurrence risk factor(P<0.05).Conclusion The recurrence of platinum-resistant ovarian cancer is related to vascular cancer embolus,abdominal water volume at initial treatment,cancer cells in ascites,FIGO stage,abnormal HE4,CA125,AIB,LMR,PLR and other factors,which should attract clinical attention and attention,and give early targeted treatment to minimize the recurrence rate.

关 键 词：铂耐药 卵巢癌 复发 相关因素 

分 类 号：R737.31[医药卫生—肿瘤]