慢性根尖周炎根周微生物分布特征及致病机制的研究进展  

Research progress on distribution characteristics and pathogenesis of periapical microorganisms in chronic periapical periodontitis

作　　者：陈彦任 邓淑丽[1] 陈卓[1] Chen Yanren;Deng Shuli;Chen Zhuo(Zhejiang University Cancer Center,Zhejiang Provincial Key Laboratory of Oral Biomedical Research,Zhejiang Oral Disease Clinical Medical Research Center,Zhejiang University School of Stomatology,Stomatology Hospital of Zhejiang University School of Medicine,Hangzhou 310000,Zhejiang Province,China)

机构地区：[1]浙江大学医学院附属口腔医院、浙江大学口腔医学院、浙江省口腔疾病临床医学研究中心、浙江省口腔生物医学研究重点实验室、浙江大学癌症研究院,杭州310000

出　　处：《中国基层医药》2024年第4期622-626,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省“尖兵”“领雁”研发攻关计划(2022C03060)。

摘　　要：根尖周炎是微生物因素与宿主根周组织炎症反应相互作用的结果,其中,细菌及其产物是根尖周炎发生、进展和传播的主要因素。牙髓感染和根尖周病变以革兰阴性菌为主,这类菌群的内毒素脂多糖(LPS)在根管感染中具有重要作用,可导致临床症状、炎症反应和骨组织吸收。革兰阳性菌中的脂磷壁酸(LTA)和LPS具有相似的致病特性,可导致牙髓和根尖周组织损伤。该综述旨在探讨慢性根尖周炎根周微生物分布特征及致病机制。Periapical periodontitis arises from the interaction between microbial factors and the inflammatory response of the host's periapical tissues.In this process,bacteria and their byproducts serve as the primary drivers for the initiation,progression,and spread of the disease.Pulp infections and periapical lesions are primarily dominated by gram-negative bacteria.The endotoxin lipopolysaccharide component of these bacteria plays a crucial role in pulp infection,triggering clinical symptoms,inflammatory reactions,and bone tissue resorption.Similarly,lipoteichoic acid and lipopolysaccharide from gram-positive bacteria exhibit similar pathogenic characteristics,causing damage to pulp and periapical tissues.The aim of this review is to delve deeper into the distribution patterns and pathogenesis of periapical microorganisms in chronic periapical periodontitis.

关 键 词：根尖周炎 细菌 毒力 防御机制 综述 

分 类 号：R781.34[医药卫生—口腔医学]