宫颈病变患者中高危型HPV检测及其临床价值  

Detection of High-Risk HPV in Patients With Cervical Lesions and Its Clinical Value

作　　者：王雪娟 王兰兰 李德玲 邹佳宏 蓝青芳 WANG Xuejuan;WANG Lanlan;LI Deling;ZOU Jiahong;LAN Qingfang(Department of Gynecology,Rongcheng Maternal and Child Health Hospital,Rongcheng Shandong 264300,China;Department of Obstetrics,Rongcheng Maternal and Child Health Hospital,Rongcheng Shandong 264300,China;Department of Ultrasound,Rongcheng Maternal and Child Health Hospital,Rongcheng Shandong 264300,China;Department of Anesthesiology,Rongcheng Maternal and Child Health Hospital,Rongcheng Shandong 264300,China;Department of Surgery,Rongcheng Maternal and Child Health Hospital,Rongcheng Shandong 264300,China)

机构地区：[1]荣成市妇幼保健院妇科,山东荣成264300 [2]荣成市妇幼保健院产科,山东荣成264300 [3]荣成市妇幼保健院超声科,山东荣成264300 [4]荣成市妇幼保健院麻醉科,山东荣成264300 [5]荣成市妇幼保健院外科,山东荣成264300

出　　处：《中国卫生标准管理》2024年第8期25-29,共5页China Health Standard Management

摘　　要：目的通过对宫颈病变患者进行高危型人乳头状瘤病毒(human papilloma virus,HPV)检测,分析总结不同宫颈病变患者HPV感染亚型特点。方法选取荣成市妇幼保健院2022年1月—2023年12月“两癌”筛查患者中1000例宫颈病变患者,对其均实施HPV检测。分析相关感染亚型,总结高致病性HPV感染亚型并分析不同程度宫颈病变患者的年龄分布情况。结果1000例患者中HPV阳性检出率为37.70%,HPV阳性检出率随着年龄的增加呈现出升高趋势;不同级别宫颈病变以单一感染为主;确诊为子宫颈癌患者的HPV感染亚型主要是HPV16型、HPV18型、HPV33型;随着患者年龄的增加,患者宫颈病变程度的增加,呈现出升高趋势。结论高危型HPV检测对子宫颈癌筛查与诊断有重要价值,能够为子宫颈癌的早期诊断治疗提供参考,宫颈病变患者中高危型HPV亚型主要为HPV16型、HPV18型、HPV33与HPV51型,针对此亚型患者应结合其他方法检查,警惕子宫颈癌风险。Objective Through the detection of high-risk human papilloma virus(HPV)in patients with cervical lesions,the characteristics of HPV infection subtypes in patients with different cervical lesions were analyzed and summarized.Methods The research subjects were 1000 patients with cervical lesions among the two cancer screening patients at Rongcheng Maternal and Child Health Hospital from January 2022 to December 2023.HPV testing was performed on all patients,and relevant infection subtypes were analyzed.High pathogenic HPV infection subtypes were summarized,and the age distribution of patients with varying degrees of cervical lesions was analyzed.Results The positive rate of HPV in 1000 patients was 37.70%,and the positive rate of HPV showed an increasing trend with the increase of age.The cervical lesions of different grades were mainly caused by single infection.The HPV infection subtypes of patients diagnosed with cervical cancer were mainly HPV16,HPV18 and HPV33.With the increase of age,the degree of cervical lesions of patients increased,showing an increasing trend.Conclusion High risk HPV testing has important value for screening and diagnosis of cervical cancer,and can provide reference for early diagnosis and treatment of cervical cancer.The high-risk HPV subtypes in patients with cervical lesions in coastal areas are mainly HPV16,HPV18,HPV33,and HPV51.Patients with this subtype should be tested with other methods to be vigilant against the risk of cervical cancer.

关 键 词：宫颈病变 子宫颈癌 高危型HPV HPV亚型 检测价值 单一感染 

分 类 号：R737[医药卫生—肿瘤]