肝癌动物模型研究进展  

Progress in animal models of liver cancer

作　　者：郭春香 余力君 杜琰 冯晓异 陈文慧 GUO Chunxiang;YU Lijun;DU Yan;FENG Xiaoyi;CHEN Wenhui(School of Basic Medicine Sciences of Yunnan University of CM,Kunming,Yunnan,650500,China;Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine,Kunming,Yunnan,650500,China)

机构地区：[1]云南中医药大学基础医学院,云南昆明650500 [2]云南省中医药学分子生物学重点实验室,云南昆明650500

出　　处：《当代医学》2024年第4期184-188,共5页Contemporary Medicine

基　　金：国家自然科学基金(82160898、81760818、82060737);云南省科技厅科技计划项目基础研究专项(202001AT070122)。

摘　　要：建立适合的动物模型是研究肝癌致病因素、分子机制、药物药效研究的重要工具,是药物评价和实验成败的关键因素。本文通过查阅、整理相关文献,从诱发性、移植型和转基因型等方面对肝癌动物模型的研究进行综述。旨在为肝癌机制探讨和药物开发等科研工作选用科学合理、操作便捷的动物模型提供参考。Selecting a suitable animal model is an important tool for studying the pathogenenic factors,molecular mechanism and drug efficacy of liver cancer,and is a key factor for drug evaluation and experiment success.This paper summarized and analyzed study on animal models of liver cancer from the aspects of inducing,transplantable and transgenic through consulting and sorting out relevant literature.To provide a basic reference for scientific and reasonable animal models with convenient operation in scientific research work such as liver cancer mechanism discussion and drug development.

关 键 词：肝癌 动物模型 致病因素 分子机制 研究进展 

分 类 号：R735.7[医药卫生—肿瘤] R-332[医药卫生—临床医学]