红景天注射液与丁苯酞注射液对帕金森患者血清DJ-1/Nrf2通路相关氧化应激指标的差异比较  

Comparison of Differences in Serum DJ-1/Nrf2 Pathway-related Oxidative Stress Indicators in Parkinson's Patients Treated with Rhodiola Injection and Dibenzoylmethane Injection

作　　者：谷伟[1] 孙梓旭 孙光宁 杨继雷[1] 贾海莉 王燕 王宏 GU Wei;SUN Zi-xu;SUN Guang-ning;YANG Ji-lei;JIA Hai-li;WANG Yan;WANG Hong(General practice,The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,075000,China;Department of Geriatrics,The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,075000,China;International medical Department,The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,075000,China)

机构地区：[1]河北北方学院附属第一医院全科医学科,河北张家口075000 [2]河北北方学院附属第一医院老年病科,河北张家口075000 [3]河北北方学院附属第一医院国际医疗部,河北张家口075000

出　　处：《现代生物医学进展》2024年第7期1384-1387,1363,共5页Progress in Modern Biomedicine

基　　金：河北省卫生健康委科研课题(20231460,20220622)。

摘　　要：目的:探讨红景天注射液与丁苯酞注射液对帕金森患者血清DJ-1/Nrf2通路相关氧化应激指标的差异。方法:本研究为前瞻性研究,以河北北方学院附属第一医院2020年8月-2022年9月住院治疗的帕金森患者120例作为研究对象,按照随机分组原则,将以上患者随机分为研究组以及对照组,所有患者均采取丁苯酞注射液治疗。研究组患者在此基础上联合采取红景天注射液治疗,连续治疗2周。比较两组患者的治疗效果、氧化应激反应指标、炎性指标、DJ-1/Nrf2通路指标之间的差异。结果:相比对照组(91.67%)而言,研究组(78.33%)患者的治疗的总有效率显著升高(x^(2)=4.181,P-0.000);经过治疗后,两组患者的SOD、MDA显著改善,且研究组患者的SOD显著高于对照组,MDA显著低于对照组;研究组患者的IL-1β(t=16.132,P=0.000)TNF-α(t=3.750,P-0.000)以及IL-6(t=2.515,P=0.013)显著低于对照组;两组患者的DJ-1以及Nrf2水平均显著上升,且研究组患者的DJ-1以及Nrf2水平显著高于对照组。结论:帕金森患者采取红景天注射液与丁苯酞注射液进行治疗,患者的血清DJ-1/Nrf2通路相关氧化应激指标得到显著的改善,治疗效果显著。Objective:To explore the differences in serum DJ-1/Nrf2 pathway-related oxidative stress indicators in Parkinson's patients treated with Rhodiola injection and Dibenzoylmethane injection.Methods:This study was a prospective study.A total of 120 Parkinson's patients who were hospitalized for treatment at the First Hospital Affiliated to North China University from August 2020 to September 2022 were selected as the research objects.According to the principle of random grouping,these patients were randomly divided into a study group and a control group,and all patients received treatment with Dibenzoylmethane injection.The study group also received treatment with Rhodiola injection for two weeks.The differences in treatment effect,oxidative stress response indicators,inflammatory indicators,and DJ-1/Nrf2 pathway indicators were compared between the two groups of patients.Results:Compared with the control group(91.67%),the total effective rate of treatment in the study group(78.33%)was significantly increased(x^(2)=4.181,P-0.000);after treatment,SOD and MDA levels were significantly improved in both groups of patients,and SOD levels were significantly higher while MDA levels were significantly lower in the study group than those in the control group;IL-1β(t-16.132,P-0.000),TNF-α(t=3.750,P-0.000)and IL-6(t=2.515,P-0.013)levels were significantly lower in the study group than those in the control group;both groups of patients showed significant increases in DJ-1 and Nrf2 levels,and DJ-1 and Nrf2 levels were significantly higher in the study group than those in the control group.Conclusion:Treatment of Parkinson's patients with Rhodiola injection and Dibenzoylmethane injection significantly improved serum DJ-1/Nrf2 pathway-related oxidative stress indicators,and the treatment effect was significant.

关 键 词：帕金森 红景天 丁苯酞 DJ-1/Nrf2 氧化应激 

分 类 号：R742.5[医药卫生—神经病学与精神病学]