基于炎症和氧化应激探讨固本明目颗粒联合玻璃酸钠滴眼液治疗白内障超声乳化术后干眼症的疗效及作用机制  

Explore the Efficacy and Mechanism of Guben Mingmu Granules Combined with Sodium Hyaluronate Eye Drops in the Treatment of Xerophthalmia after Cataract Phacoemulsification Based on Inflammation and Oxidative Stress

作　　者：徐家窈[1] 郑海生[1] 陈海燕 冼文光[2] 欧阳博文 XU Jia-yao;ZHENG Hai-sheng;CHEN Hai-yan;XIAN Wen-guang;OUYANG Bo-wen(Department of Corneology,Hainan Ophthalmology Hospital of Ophthalmology Center of Sun Yat Sen University/Hainan Key Laboratory of Ophthalmology/Hainan Ophthalmology Hospital,Haikou,Hainan,570311,China;Department of Fundus Diseases,Hainan Ophthalmology Hospital of Ophthalmology Center of Sun Yat Sen University/Hainan Key Laboratory of Ophthalmology/Hainan Ophthalmology Hospital,Haikou,Hainan,570311,China)

机构地区：[1]中山大学中山眼科中心海南眼科医院/海南省眼科学重点实验室/海南省眼科医院角膜科,海南海口570311 [2]中山大学中山眼科中心海南眼科医院/海南省眼科学重点实验室/海南省眼科医院眼底病科,海南海口570311

出　　处：《现代生物医学进展》2024年第7期1388-1391,1374,共5页Progress in Modern Biomedicine

基　　金：海南省自然科学基金面上项目(819MS133)。

摘　　要：目的:基于炎症和氧化应激探讨固本明目颗粒联合玻璃酸钠滴眼液治疗白内障超声乳化术后干眼症的疗效及作用机制。方法:根据随机数字表法将2021年3月到2022年8月海南省眼科医院期间收治的150例白内障超声乳化术后干眼症患者分为观察组(固本明目颗粒联合玻璃酸钠滴眼液治疗,75例)、对照组(玻璃酸钠滴眼液治疗,75例)。对比两组疗效、安全性、眼部相关指标、炎症因子、症状评分和氧化应激水平。结果:治疗后,与对照组相比,观察组的临床总有效率更高,泪液分泌试验(SIt)、眼泪膜破裂时间(BUT)更高;干涩感、异物感、视疲劳症状评分和总评分更低;肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)更低;丙二醛(MDA)、脂质过氧化物(LPO)更低,超氧化物歧化酶(SOD)更高(P<0.05)。两组不良反应发生率组间对比未见差异(P>0.05)。结论:在玻璃酸钠滴眼液治疗的基础上联合固本明目颗粒治疗白内障超声乳化术后干眼症,可缓解干眼症状,提高临床总有效率,可能与调节患者体内炎症因子、氧化应激水平有关。Objective:To explore the efficacy and mechanism of Guben Mingmu granules combined with sodium hyaluronate eye drops in the treatment of xerophthalmia after cataract phacoemulsification based on inflammation and oxidative stress.Methods:150 patients with xerophthalmia after cataract phacoemulsification admitted to Hainan Ophthalmology Hospital from March 2021 to August 2022 were divided into observation group(guben mingmu granules combine with sodium hyaluronate eye drops,75 case)and control group(sodium hyaluronate eye drops,75 cases)according to the random number table method.The efficacy,safety,eye-related indicators,inflammatory factors,symptom scores and oxidative stress levels were compared between two groups.Results:After treatment,compared with control group,the total clinical effective rate in observation group was higher,the tear secretion test(SIt)and tear film rupture time(BUT)were higher;the dryness,foreign body sensation,visual fatigue symptom scores and total scores were lower;the tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were lower;malondialdehyde(MDA)and lipid peroxide(LPO)were lower,and superoxide dismutase(SOD)was higher(P<0.05).There was no difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:The combination of guben mingmu granules on the basis of sodium hyaluronate eye drops for xerophthalmia after cataract phacoemulsification,which can alleviate the symptoms of xerophthalmia,and improve the total clinical effective rate,it may be relate to the regulation of inflammatory factors and oxidative stress levels in patients.

关 键 词：固本明目颗粒 玻璃酸钠滴眼液 白内障超声乳化术 干眼症 炎症 氧化应激 作用机制 

分 类 号：R776.1[医药卫生—眼科] R777[医药卫生—临床医学]