近视眼像差与人眼客观焦深的关联性分析  

Correlation analysis of myopia aberration and objective depth of focus in the human eye

作　　者：张明栋 王雁[1] 赵新恒 Zhang Mingdong;Wang Yan;Zhao Xinheng(Clinical School of Ophthalmology,Tianjin Medical University,Tianjin Eye Hospital,Tianjin Eye Institute,Tianjin Key Laboratory of Ophthalmology and Vision Science,Affiliated Eye Hospital,Nankai University,Institute of Ophthalmology,Nankai University,Tianjin 300020,China)

机构地区：[1]天津医科大学眼科临床学院、天津市眼科医院、天津市眼科研究所、天津市眼科学与视觉科学重点实验室、南开大学附属眼科医院、南开大学眼科学研究院,天津300020

出　　处：《中华实验眼科杂志》2024年第4期347-353,共7页Chinese Journal Of Experimental Ophthalmology

基　　金：国家重点研发计划(2022YFC2404502);国家自然科学基金面上项目(82271118);天津市科技计划(21JCZDJC01190);天津市卫生健康科技项目(TJWJ2022XK036);天津市医学重点学科(专科)建设项目(TJYXZDXK-016A)。

摘　　要：目的探讨低、高阶像差与人眼客观焦深的关联性及影响客观焦深的因素。方法采用横断面研究,选取2022年2—4月在天津市眼科医院屈光手术中心就诊的近视及散光患者76例152眼,其中男41例,女35例。采用iTrace视功能分析仪手动选择3、4、5和6 mm 4个扫描直径,对患者的全眼低阶像差和高阶像差进行测量,同时直接测得患者在该瞳孔直径下的客观焦深。采用Spearman秩相关性分析评估不同瞳孔直径下客观焦深与低、高阶像差之间的相关性;对不同程度近视和散光人群及不同瞳孔直径、眼别、性别间的客观焦深进行比较。结果客观焦深与总低阶像差在3、4、5、6 mm瞳孔直径下均呈正相关(r_(s)=0.380、0.317、0.385、0.519,均P<0.01)。客观焦深与离焦(近视度)在3、4、5、6 mm瞳孔直径下均呈正相关(r_(s)=0.377、0.323、0.403、0.512,均P<0.01),与像散(散光度)仅在瞳孔直径为6 mm时呈正相关(r_(s)=0.255,P<0.05)。3、4、5、6 mm瞳孔直径下不同近视程度组客观焦深总体比较差异均有统计学意义(H=6.440、7.370、9.990、16.930,均P<0.05),其中不同瞳孔直径下高度近视组客观焦深均明显高于低度近视组,6 mm瞳孔直径下高度近视组客观焦深高于中度近视组,差异均有统计学意义(均P<0.05)。客观焦深与总高阶像差在3、4、5、6 mm瞳孔直径下均呈正相关(r_(s)=0.911、0.807、0.733、0.677,均P<0.001)。在各项高阶像差中,客观焦深与总彗差在3、4、5、6 mm瞳孔直径下均呈正相关(r_(s)=0.727、0.557、0.620、0.487,均P<0.001);与垂直彗差在3、4、5、6 mm瞳孔直径下均呈正相关(r_(s)=0.439、0.405、0.553、0.400,均P<0.001);与水平彗差在瞳孔直径为5 mm和6 mm时均呈正相关(r_(s)=0.308、0.308,均P<0.01);与三叶草像差在3、4、5、6 mm瞳孔直径下均呈正相关(r_(s)=0.344、0.443、0.316、0.330,均P<0.01);与球差在瞳孔直径为4、5和6 mm时均呈正相关(r_(s)=0.321、0.310、0.428,均Objective To investigate the correlation between low-order and high-order aberrations and objective depth of focus in the human eye,and the factors that influence objective depth of focus.Methods A cross-sectional study was performed.Seventy-six patients(152 eyes)with myopia and astigmatism patients who were treated at the Refractive Surgery Center of Tianjin Eye Hospital from February to April 2022 were selected,including 41 males and 35 females.The patients'whole-eye low-order and high-order aberrations and objective depth of focus were measured at 3,4,5,and 6 mm manually selected pupil diameters using the iTrace visual function analyzer.The correlation between objective depth of focus and low-order and high-order aberrations at different pupil diameters was analyzed by Spearman rank correlation analysis.Objective depth of focus was compared between individuals with different degrees of myopia and astigmatism,individuals with different pupil diameters,right and left eyes,and different sexes.This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Tianjin Eye Hospital(No.2022039).Results Objective depth of focus was positively correlated with total low-order aberrations at 3,4,5,and 6 mm pupil diameter(r_(s)=0.380,0.317,0.385,0.519,all at P<0.01).Objective depth of focus was positively correlated with defocus at 3,4,5,and 6 mm pupil diameter(r_(s)=0.377,0.323,0.403,0.512,all at P<0.01),and with astigmatism at 6 mm pupil diameter(r_(s)=0.255,P<0.05).There were statistically significant overall differences in objective depth of focus between groups with different degrees of myopia at 3,4,5,and 6 mm pupil diameter(H=6.440,7.370,9.990,16.930;all at P<0.05).Among them,the objective depth of focus of high myopia was significantly higher than that of low myopia at different pupil diameters,and the objective depth of focus of high myopia was higher than that of moderate myopia at 6 mm pupil diameter,with statistically significant differences(all at P<0.05).Objective de

关 键 词：近视 像差 视觉质量 客观焦深 低阶像差 高阶像差 

分 类 号：R778.11[医药卫生—眼科]