持续性静脉泵入咪达唑仑治疗小儿癫痫持续状态的效果及对患儿血清各项因子水平的影响  

The effect of continuous intravenous pumping of midazolam in the treatment of status epilepticus in children and its effect on the serum levels of various factors

作　　者：冯娟 杨家武[2] 彭海燕[1] FENG Juan;YANG Jiawu;PENG Haiyan(Department of Pediatrics,Ganmei Hospital,Kunming First People's Hospital,Kunming,Yunnan,650000,China;Department of Respiratory and Critical Care Medicine,Children's Hospital of Kunming,Kunming,Yunnan,650000,China)

机构地区：[1]昆明市第一人民医院甘美医院儿科,云南昆明650000 [2]昆明市儿童医院呼吸与危重症医学科,云南昆明650000

出　　处：《当代医学》2024年第3期14-18,共5页Contemporary Medicine

摘　　要：目的探究持续性静脉泵入咪达唑仑治疗小儿癫痫持续状态的效果及对患儿血炎症因子和脑源性神经营养因子(BDNF)、甘丙肽(GAL)、血神经肽Y(NPY)水平的影响。方法选取2019年3月至2021年11月昆明市第一人民医院甘美医院收治的82例癫痫持续状态患儿作为研究对象,按照随机数字表法分为对照组与观察组,每组41例。对照组给予地西泮治疗,观察组给予咪达唑仑治疗。比较两组临床疗效、炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)]水平、发病情况、血清学指标(BDNF、GAL、NPY)及不良反应发生情况。结果观察组治疗总有效率为92.68%,高于对照组的75.61%,差异有统计学意义(P<0.05)。治疗后,两组IL-6、TNF-α、IL-1水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组发病间隔时间均长于治疗前,发病持续时间均短于治疗前,且观察组发病间隔时间长于对照组,发病持续时间短于对照组,差异有统计学意义(P<0.05)。治疗后,两组BDNF、GAL、NPY水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为4.88%,低于对照组的19.51%,差异有统计学意义(P<0.05)。结论持续性静脉泵入咪达唑仑治疗小儿癫痫持续状态效果良好,可缩短癫痫持续时间及发病间隔时间,改善患儿体内炎症因子及血清学指标,减少不良反应发生情况。Objective To explore the effect of continuous intravenous pumping of midazolam in the treatment of status epilepticus in children and its effect on the serum levels of inflammatory factors,brain-derived neurotrophic factor(BDNF),galanin(GAL)and neuropeptide Y(NPY)in children.Methods A total of 82 children with status epilepticus admitted to Ganmei Hospital,Kunming First People's Hospital from March 2019 to November 2021 were selected as the research subjects,they were divided into the control group and the observation group according to the random number table method,with 41 cases in each group.The control group was treated with diazepam,and the observation group was treated with midazol-am.The clinical efficacy,inflammatory factors(interleukin-6[IL-6],tumor necrosis factor-α[TNF-α],interleukin-1[IL-1])levels,incidence of dis-ease,serum indicators(BDNF,GAL,NPY)and adverse reactions were compared between the two groups.Results The total effective rate of treat-ment in the observation group was 92.68%,which was higher than 75.61%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of IL-6,TNF-αand IL-1 of the two groups were lower than those before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).After treatment,the interval time of onset of the two groups was longer than that before treatment,the duration of onset was shorter than that before treatment,and the interval time of onset in the observation group was longer than that in the control group,the duration of onset was shorter than that in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of BDNF,GAL and NPY of the two groups were lower than those before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 4.88%,which was lower than 19.51%in the cont

关 键 词：咪达唑仑 炎症因子 癫痫持续状态 

分 类 号：R742.1[医药卫生—神经病学与精神病学]