全胸腔镜食管癌根治术治疗食管癌的效果及对患者血清炎症因子水平和肺功能的影响  

Effect of total thoracoscopic radical resection for esophageal cancer and its influence on serum inflammatory factors and lung function

作　　者：查健 冯家宁 陆剑豪 ZHA Jian;FENG Jianing;LU Jianhao(Department of Cardiothoracic and Breast Surgery,Guangdong Tongjiang Hospital,Foshan,Guangdong,528300,China)

机构地区：[1]广东同江医院心胸乳腺外科,广东佛山528300

出　　处：《当代医学》2024年第3期80-82,共3页Contemporary Medicine

摘　　要：目的探讨全胸腔镜食管癌(EC)根治术治疗食管癌的效果及对患者血清炎症因子水平和肺功能的影响。方法选取2019年7月至2020年10月广东同江医院接诊且行全胸腔镜食管癌根治术的38例EC患者作为观察组,另选取同期接诊且行传统开胸手术的38例EC患者作为对照组,比较两组围手术期指标、血清炎症因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]、肺功能指标[每分钟最大通气量(MVV)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)]及并发症发生率。结果两组清扫淋巴结数比较差异无统计学意义;观察组术中失血量、总引流量少于对照组,手术时间短于对照组,差异有统计学意义(P<0.05)。术前,两组CRP、TNF-α水平比较差异无统计学意意义;术后72h,两组CRP、TNF-α水平均高于术前,但观察组低于对照组,差异有统计学意义(P<0.05)。术前,两组MVV、FVC、FEV1比较差异无统计学意意义;术后2周,两组MVV、FVC、FEV1均低于术前,但观察组MVV、FVC、FEV1均高于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论全胸腔镜食管癌根治术治疗EC疗效显著,能改善患者术后炎症因子水平,对患者肺功能影响小,且并发症少,值得临床推广应用。Objective To investigate the effect of total thoracoscopic radical resection for esophageal cancer(EC)and its influence on serum in-flammatory factors and lung function.Methods A total of 38 EC patients admitted to Guangdong Tongjiang Hospital from July 2019 to October 2020 who underwent total thoracoscopic radical resection for esophageal cancer were selected as the observation group,and another 38 EC patients admitted to Guangdong Tongjiang Hospital during the same period who underwent traditional thoracotomy were selected as the control group.Periop-erative indexes,serum inflammatory factors(C-reactive protein[CRP],tumor necrosis factor-α[TNF-α]),lung function indexes(maximum gas vol-ume per minute[MVV],forced lung capacity[FVC],forced expiratory volume in the first second[FEV1])and complication rate were compared be-tween the two groups.Results There was no significant difference in the number of lymph nodes between the two groups;the intraoperative blood loss and total drainage volume in the observation group were less than those in the control group,and the operative time was shorter than that in the control group,the differences were statistically significant(P<0.05).Before operation,there were no significant differences in CRP and TNF-αlev-els between the two groups;72 h after operation,the levels of CRP and TNF-αof the two groups were higher than before operation,but the observa-tion group was lower than the control group,the differences were statistically significant(P<0.05).Before operation,there were no significant differ-ences in MVV,FVC and FEV1 between the two groups;2 weeks after operation,MVV,FVC and FEV1 of the two groups were lower than before opera-tion,but MVV,FVC and FEV1 in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Total thoracoscopic radical resectio

关 键 词：全胸腔镜食管癌根治术 治疗效果 C反应蛋白 肿瘤坏死因子-Α 肺功能 

分 类 号：R735.1[医药卫生—肿瘤]