幽门螺杆菌感染与结直肠息肉发生的关系  

The correlation of Helicobacter pylori infection with colorectal polyps

作　　者：王义 李英女[2] 刘家瑜 王东明[4] 王允野[1] WANG Yi;LI Yingnyu;LIU Jiayu;WANG Dongming;WANG Yunye(Department of Gastroenterology,the Affiliated Hospital of Jilin Medical College,Jilin,Jilin,132001,China;Department of Pathology,the Affiliated Hospital of Jilin Medical College,Jilin,Jilin,132001,China;Endoscopy Room,the Affiliated Hospital of Jilin Medical College,Jilin,Jilin,132001,China;Department of Gastroenterology,Jilin Central Hospital,Jilin,Jilin,132002,China)

机构地区：[1]吉林医药学院附属医院消化内科,吉林吉林132001 [2]吉林医药学院附属医院病理科,吉林吉林132001 [3]吉林医药学院附属医院窥镜室,吉林吉林132001 [4]吉林市中心医院消化内科,吉林吉林132002

出　　处：《当代医学》2024年第3期124-127,共4页Contemporary Medicine

基　　金：吉林省卫生健康科技能力提升计划项目(2021LC040)。

摘　　要：目的探讨幽门螺杆菌(Hp)感染与结直肠息肉发生的关系。方法选取2021年6月至2022年6月分别于吉林医药学院附属医院及吉林市中心医院内镜室行结肠镜检查并经病理确诊为结直肠息肉的242例患者作为病例组,并选取同期结肠镜检查无异常的健康者155名作为对照组。所有研究对象同期完成14C尿素呼气试验,统计结直肠息肉患者Hp阳性感染率,并分析息肉临床特征如大小、数量、位置、病理分型的Hp阳性感染率。采用Logistic回归分析结直肠息肉发生的独立危险因素,分析患者结直肠息肉Hp感染检测值(dpm)与息肉临床特征的关系。结果病例组年龄大于对照组,男性及Hp阳性占比均高于对照组,差异有统计学意义(P<0.05)。病例组左半结肠息肉、多发息肉、腺瘤性息肉、直径≥0.5cm的息肉患者Hp阳性感染率均高于对照组,差异有统计学意义(P<0.005)。Logistic回归分析结果显示,年龄、性别、Hp感染是结直肠息肉发生的独立危险因素(P<0.05)。病例组及结直肠息肉(左半结肠)、结直肠息肉(多发)、结直肠息肉(腺瘤组)、结直肠息肉(直径≥0.5cm)Hp阳性感染患者14C检测平均dpm值与对照组比较差异无统计学意义。结论Hp感染对结直肠息肉的发生有影响,年龄、性别、Hp感染是结直肠息肉发生的危险因素,Hp感染在结直肠息肉的位置、数量、病理类型、大小方面存在明显差异,但Hp阳性感染检测值在结直肠息肉的临床特征中无差异,对于HP感染的患者有必要进行肠镜筛查结直肠息肉,做到早诊早治。Objective To investigate the correlation of Helicobacter pylori(Hp)infection with colorectal polyps.Methods 242 patients who un-derwent colonoscopy in the Endoscopy Room of the Affiliated Hospital of Jilin Medical College and the Endoscopy Room of Jilin Central Hospital from June 2021 to June 2022 were pathologically diagnosed as colorectal polyps were selected as the case group,and 155 healthy subjects without abnormal colonoscopy during the same period were selected as the control group.All subjects completed the 14C urea breath test at the same time,the Hp positive infection rate of patients with colorectal polyps was counted,and the Hp positive infection rate of clinical features such as size,number,location and pathological classification of polyps were analyzed,Logistic regression analysis was used to analyze the independent risk factors of colorectal polyps,and the relationship between the detection value of Hp infection(dpm)in colorectal polyps and the clinical characteristics of pol-yps was analyzed.Results The age in the case group was higher than that in the control group,and the proportion of male and Hp positive were higher than those in the control group,the differences were statistically significant(P<0.05).The Hp positive infection rate of patients with left co-lon polyps,multiple polyps,adenomatous polyps and polyps with diameter≥0.5 cm in the case group were higher than those in the control group,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that age,gender and Hp infection were independent risk factors for colorectal polyps(P<0.05).There were no significant differences in the average dpm value of 14C detection in patients with Hp posi-tive infection in colorectal case group,colorectal polyps(left colon),colorectal polyps(multiple),colorectal polyps(adenoma group)and colorectal polyps(diameter≥0.5 cm)group compared with normal control group.Conclusion Hp infection is associated with the colorectal polyps,age,sex and Hp infection were independe

关 键 词：幽门螺杆菌感染 结直肠息肉 危险因素 检测值 

分 类 号：R573[医药卫生—消化系统]