2018年四川省肿瘤医院食管癌外科手术治疗数据报告  

Annual Data Report on Surgical Treatment of Esophageal Cancer in Si⁃chuan Cancer Hospital in 2018

作　　者：熊继承 陆思秒 谢钦 彭林[2] 方强[2] 肖文光[2] 乔良[3] 缪艳[2] 韩泳涛[2] 冷雪峰 Xiong Jicheng;Lu Simiao;Xie Qin;Peng Lin;Fang Qiang;Xiao Wenguang;Qiao Liang;Miao Yan;Han Yongtao;Leng Xuefeng(Department of Clinical Medicine,School of Medicine,University of Electronic Science and Technology,Chengdu 610000,Sichuan,China;Department of Thoracic Surgery,Sichuan Clinical Research Center for Cancer,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,Affiliated Cancer Hospital of University of Electronic Science and Technology of China,Chengdu 610041,Sichuan,China;Prevention Department,Sichuan Clinical Research Center for Cancer,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,Affiliated Cancer Hospital of University of Electronic Science and Technology of China,Chengdu 610041,Sichuan,China)

机构地区：[1]电子科技大学医学院临床系,成都610000 [2]四川省肿瘤临床医学研究中心,四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学附属肿瘤医院胸外科,成都610041 [3]四川省肿瘤临床医学研究中心,四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学附属肿瘤医院预防部,成都610041

出　　处：《肿瘤预防与治疗》2024年第4期292-300,共9页Journal of Cancer Control And Treatment

基　　金：国家重点研发计划(编号:2022YFC2403400);四川省科技厅重点研发项目(编号:2023YFS0044);四川省国际科技创新合作项目(编号:2020YFH0169);吴阶平医学基金会临床科研专项资助基金(编号:320.6750.2020-15-3);四川省临床重点专科建设项目([2022]70)。

摘　　要：目的:通过分析2018年四川省肿瘤医院通过规范化外科手术及多学科治疗食管癌的数据,为国内食管癌的外科手术治疗及多学科治疗提供参考。方法:回顾性分析2018年四川省肿瘤医院通过规范化外科治疗及多学科治疗的265例食管癌患者临床及病理资料,对其肿瘤生物学特性及术后远期效果进行分析。结果:本组食管癌患者以60~69岁年龄段为主(45.7%),其中男性220例、女性45例;进行外科手术263例,行内镜下切除术2例。术后病理结果均为鳞状细胞癌。肿瘤位于胸中段者136例(51.3%)。接受术前新辅助治疗64例(24.2%),接受直接手术者199例(75.1%),240例患者行McKeown术式(90.6%),微创手术238例(90.5%)。淋巴结平均清扫个数(21±12)枚,淋巴结平均清扫站数(7±2)站。术后61例(23.0%)患者接受了辅助治疗。R0切除率为98.5%(261/265)。R0切除术后1、3、5年总生存率依次为85.8%、63.6%和54.4%。R0切除术后1、3、5年无病生存期依次为79.1%、60.4%和52.1%。结论:通过规范化外科手术治疗及多学科治疗,实现R0切除及系统性淋巴结清扫,食管癌患者可获得较为满意的长期生存结果。Objective:To provide reference values for the surgical treatment and multidisciplinary treatment of esophageal cancer in China through analyzing the data of esophageal cancer treated by standardized surgery and multidisciplinary treat⁃ment in Sichuan Cancer Hospital in 2018.Methods:We retrospectively analyzed 265 esophageal cancer patients treated through standardized surgical treatment and multidisciplinary treatment in Sichuan Cancer Hospital in 2018 and analyzed their tumor biological characteristics and postoperative long⁃term effects.Results:The patients with esophageal cancer were main⁃ly in 60~69 years old(45.7%),including 220 males and 45 females,among them,263 cases underwent esophagectomy and 2 cases underwent endoscopic submucosal dissection.Postoperative pathological results of all patients were squamous cell carcinoma.136 cases(51.3%)had their tumors located in the mid⁃thoracic segment.64 cases(24.2%)received neoad⁃juvant therapy,and 199 cases(75.1%)opted for direct surgery.McKeown procedure was performed in 240 patients(90.6%),minimally invasive surgery in 238 patients(90.5%).The average number of dissected lymph nodes was 21±12,and the mean number of lymph node stations dissected was 7±2.Sixty⁃one patients(23.0%)received adjuvant therapy after surgery.The R0 resection rate was 98.5%(261/265).The 1⁃,3⁃and 5⁃year overall survival rate after R0 resection were 85.8%,63.6%and 54.4%,respectively.The 1⁃,3⁃and 5⁃year disease⁃free survival rate after R0 resection were 79.1%,60.4%and 52.1%,respectively.Conclusion:R0 resection and standardized lymph node dissection can be a⁃chieved through standardized surgical treatment and multidisciplinary treatment.Patients with esophageal cancer can therefore obtain more satisfactory long⁃term survival.

关 键 词：食管癌 食管切除术 多学科治疗 年度报告 

分 类 号：R735.1[医药卫生—肿瘤] R730.56[医药卫生—临床医学]