长效抗精神病药物治疗的精神分裂症病例分析  

Characteristics of schizophrenic patients using long-acting antipsychotic medications

作　　者：葛晓蕾 张伟波[1,2] 陈春梅[1,2] 朱有为[1,2] 刘彦丽[1,2] 谢斌[2,3] 蔡军 朱益 GE Xiaolei;ZHANG Weibo;CHEN Chunmei;ZHU Youwei;LIU Yanli;XIE Bin;CAI Jun;ZHU Yi(Shanghai Mental Health Center Prevention and Control Office,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;China Hospital Development Institute,Shanghai Jiao Tong University,Shanghai 200030,China;Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心防治科,上海200030 [2]上海交通大学中国医院发展研究院,上海200030 [3]上海交通大学医学院附属精神卫生中心,上海200030

出　　处：《预防医学》2024年第5期412-415,共4页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：上海市卫生健康委员会卫生行业临床研究专项(202040362);上海市公共卫生体系建设三年行动计划重点学科建设项目(GWV-10.1-XK18);上海市卫生健康委员会卫生健康政策研究课题项目(2023HP18);上海交通大学医学院科技创新项目(WK2118);上海市“医苑新星”青年医学人才培养计划项目(沪卫人事[2021]99号);上海市加强公共卫生体系建设三年行动计划学科带头人项目(GWVI-11.2-XD25);上海交通大学文科青年人才培育计划项目(2023QN038);上海交通大学2024年度“医工交叉研究基金”重点项目(YG2024ZD24)。

摘　　要：目的了解使用长效抗精神病药物治疗的精神分裂症病例特征,为长效抗精神病药物适用患者研究提供依据。方法通过上海市精神卫生信息管理系统收集2020年6月—2022年6月上海市长效抗精神病药物治疗的精神分裂症病例资料,描述性分析人口学特征、患病和服药情况。结果纳入长效抗精神病药物治疗的精神分裂症病例2684例,年龄为(46.92±12.39)岁;男性1246例,占46.42%;女性1438例,占53.58%;无业1397例,占52.05%;初中及以下学历1429例,占53.24%;未婚1301例,占48.47%;经济状况差832例,占31.00%;看护人以其父母为主,1507例占56.15%。病程以≤10年和>10~20年为主,各860例,占32.04%;自知力不全1963例,占73.14%;住院次数≥1次1570例,占58.49%。持续服药2486例,占92.62%;服药方式以他人喂药为主,1947例占72.54%;服药依从性以按时按量服药为主,2437例占90.80%。结论长效抗精神病药物治疗的精神分裂症病例以青壮年、未婚、无业、自知力不全、持续服药和他人给药为主要特征。Objective To investigate the characteristics of schizophrenic patients using long-acting antipsychotic medica⁃tions,so as to provide the basis for applicable population of long-acting antipsychotic medications.Methods Data of schizophrenic patients using long-acting antipsychotic medications in Shanghai City from June 2020 to June 2022 were collected through Shanghai Mental Health Information Management System,and demographic characteristics,illness and medication use of patients were descriptively analyzed.Results A total of 2684 schizophrenic patients using long-acting antipsychotic medications were included in the study,had a mean age of(46.92±12.39)years,with 1246 males(46.42%)and 1438 females(53.58%).There were 1397 unemployed cases,accounting for 52.05%;1429 cases with an educational level in junior high school or below,accounting for 53.24%;1301 unmarried cases,accounting for 48.47%;832 cases in poverty,accounting for 31.00%.The caregivers of patients were mainly their parents,with 1507 cases accounting for 56.15%.The courses of illness were mainly≤10 years and>10-20 years,with 860 cases each,both accounting for 32.04%;1963 cases with incomplete self-awareness,accounting for 73.14%;1570 cases hospitalized at least once,accounting for 58.49%.There were 2486 cases with continuous medication,accounting for 92.62%.The main method of taking medication was given by others,with 1947 cases accounting for 72.54%.The medication adherence was mainly taking medication on time and in the right amount,with 2437 cases accounting for 90.80%.Conclusion The main characteristics of schizophrenic patients using long-acting antipsychotic medications are young,unmarried,and unemployed adults,with incomplete self-awareness,continuous medication and medication given by others.

关 键 词：精神分裂症 长效抗精神病药物 服药依从性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]