缺血性脑小血管病患者血清3-NT、Aβ1-42、CX3CL1与认知功能障碍的相关性分析  

A Correlation Analysis of Serum 3-NT,Aβ1-42,CX3CL1 and Cognitive Dysfunction in Patients with Ischemic Small Cerebral Vascular Disease

作　　者：陆旭 黄佳滨[2] 隋小芳[2] 王凤玲[2] 陈茹星 LU Xu;HUANG Jiabin;SUI Xiaofang;WANG Fengling;CHEN Ruxing(Department of Geriatry,Jiamusi University School of Medicine,Jiamusi 154000,China;Department of Geriatrics,Jiamusi University Affiliated First Hospital,Jiamusi 154000,China;Heilongjiang University ofTraditional Chinese Medicine,Harbin 150006,China)

机构地区：[1]佳木斯大学医学院老年病科,黑龙江佳木斯154000 [2]佳木斯大学附属第一医院老年病科,黑龙江佳木斯154000 [3]黑龙江中医药大学,黑龙江哈尔滨150006

出　　处：《标记免疫分析与临床》2024年第4期703-707,720,共6页Labeled Immunoassays and Clinical Medicine

基　　金：黑龙江省中医药科研项目(编号:2020-064)。

摘　　要：目的探讨缺血性脑小血管病患者血清3-硝基酪氨酸(3-NT)、β淀粉样蛋白1-42(Aβ1-42)、趋化因子C-X3-C配体1(CX3CL1)与认知功能障碍的相关性。方法选取我院2022年12月至2023年12月收治的117例缺血性脑小血管病患者,分为认知正常组37例和认知障碍组80例,依据MoCA评分将认知障碍组分为轻度组23例、中度组27例、重度组30例,另选取30例同期健康体检者作为对照组。检测血清3-NT、Aβ1-42、CX3CL1水平,ROC曲线分析血清3-NT、Aβ1-42、CX3CL1检测诊断认知障碍的灵敏度和特异性。结果认知功能障碍组血清3-NT水平高于认知功能正常组和对照组,血清Aβ1-42、CX3CL1低于认知功能正常组和对照组(P<0.05);血清3-NT、Aβ1-42、CX3CL1异常表达与缺血性脑小血管病患者认知功能障碍有关(P<0.05);血清3-NT、Aβ1-42、CX3CL1联合检测诊断缺血性脑小血管病认知功能障碍的AUC值高于单项检测(Z_(3-NT-联合检测)=3.621,Z_(Aβ1-42-联合检测)=3.046,Z_(CX3CL1-联合检测)=2.075,P<0.05)。结论缺血性脑小血管病患者认知功能障碍与血清3-NT升高、Aβ1-42、CX3CL1降低有关。Objective To investigate the correlation between serum 3-nitrotyrosine(3-NT),β-amyloid 1-42(Aβ-1-42),chemokine C-X3-C ligand 1(CX3CL1)and cognitive dysfunction in patients with ischemic small cerebral vascular disease.Methods 117 patients with ischemic cerebrovascular disease admitted to our hospital from December,2022 to December,2023 were selected and divided into a cognitive normal group of 37 cases and a cognitive impairment group of 80 cases.Based on the MoCA score,the cognitive impairment group was divided into a mild group of 23 cases,a moderate group of 27 cases,and a severe group of 30 cases.We detected serum 3-NT,Aβ1-42,CX3CL1 levels.ROC curve was drawn for serum 3-NT and Aβ1-42.Sensitivity and specificity of CX3CL1 detection in diagnosing cognitive impairment were also evaluated.Results Serum 3-NT levels in the cognitive impairment group were higher than those in the normal cognitive function group and the control group,while serum Aβ1-42,CX3CL1 were lower than that of the normal cognitive function group and the control group(P<0.05);Serum 3-NT,Aβ1-42,and abnormal expression of CX3CL1 were associated with cognitive dysfunction in patients with ischemic small-cerebral vascular disease(P<0.05);The AUC value of combined detection of serum 3-NT,Aβ1-42 and CX3CL1 in diagnosing cognitive impairment in acute ischemic small cerebral vascular disease was higher than that of single-marker detection(Z_(3-NT-combined detection)=3.621,Z_(Aβ1-42-joint detection)=3.046,Z_(CX3CL1-joint detection)=2.075,P<0.05).Conclusion Cognitive dysfunction in patients with ischemic small cerebral vascular disease is associated with elevated serum 3-NT levels and Aβ1-42,CX3CL1 reduction.

关 键 词：脑梗死 认知功能障碍 3-硝基酪氨酸 β淀粉样蛋白1-42 趋化因子C-X3-C配体1 

分 类 号：R743[医药卫生—神经病学与精神病学]