代谢“废物”乳酸在肿瘤微环境中的免疫抑制作用  

Immunosuppressive effect of metabolic"waste"lactic acid in tumor microenvironment

作　　者：苑思羽 侯俊杰[2] 张片红[1] YUAN Siyu;HOU Junjie;ZHANG Pianhong(Department of Clinical Nutrition,the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China;Department of Tumor Comprehensive Therapy,Jilin Provincial People's Hospital,Changchun 130021,China)

机构地区：[1]浙江大学医学院附属第二医院营养科,杭州310009 [2]吉林省人民医院肿瘤综合治疗科,长春130021

出　　处：《中国免疫学杂志》2024年第4期832-839,共8页Chinese Journal of Immunology

基　　金：吉林省科技发展计划项目(20230402007GH)。

摘　　要：近年来,肿瘤微环境(TME)备受科学家们的关注,它是由肿瘤细胞、肿瘤相关成纤维细胞(CAFs)、免疫细胞、血管、细胞外基质、周围支持组织及其所在的代谢环境等共同组成的复杂体系。免疫逃逸和代谢改变(葡萄糖有氧代谢转至无氧代谢产生乳酸)是此体系的两个基本特征。虽然过去一直认为乳酸是TME中的代谢废物,但现在人们普遍认为乳酸的增加和TME的酸化在肿瘤发生发展中发挥关键作用,包括免疫逃逸、组织侵袭/肿瘤转移、血管生成和肿瘤耐药等。因此,研究TME中乳酸代谢、免疫抑制、血管生成、肿瘤耐药等关键过程的调控机制,可为靶向TME的新治疗策略提供理论基础和实践依据。In recent years,the tumor microenvironment(TME)has garnered significant attention from scientists.It is a complex system composed of tumor cells,cancer-associated fibroblasts(CAFs),immune cells,blood vessels,extracellular matrix,surrounding supportive tissues and their metabolic environment.Two fundamental characteristics of this system are immune escape and metabolic changes(the shift from aerobic to anaerobic metabolism of glucose,leading to lactate production).Although lactate has traditionally been considered a metabolic"waste"product in the TME,it is now widely recognized that the increase in lactate and the acidification of the tumor microenvironment play key roles in tumor development and progression,including immune escape,tissue invasion/tumor metastasis,angiogenesis and tumor drug resistance.Therefore,studying the regulatory mechanisms of lactate metabolism,immune suppression,angiogenesis,and tumor drug resistance in the TME can provide a theoretical basis and practical evidence for new therapeutic strategies targeting the TME.

关 键 词：乳酸代谢 免疫抑制 肿瘤微环境 

分 类 号：R730.3[医药卫生—肿瘤]