真菌毒素对树突状细胞免疫应答的影响  

Effects of mycotoxins on immune response of dendritic cells

作　　者：于欢 尚国富 欧沙 洪亮 曾柱 胡祖权 YU Huan;SHANG Guofu;OU Sha;HONG Liang;ZENG Zhu;HU Zuquan(School of Biology and Engineering,Key Laboratory of Infectious Immune and Antibody Engineering in Guizhou Province,State Key Laboratory of Func-tions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550025,China)

机构地区：[1]贵州医科大学生物与工程学院,贵州省感染免疫与抗体工程特色重点实验室,省部共建药用植物功效与利用国家重点实验室,贵阳550025

出　　处：《中国免疫学杂志》2024年第4期862-865,871,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(21906036);贵州省科技计划项目(黔科合基础-ZK[2021]重点029,黔科合支撑[2019]2787号,黔科合平台人才[2016]5676)。

摘　　要：真菌毒素是病原真菌产生的次级代谢产物,常污染多种农作物,通过食物链对人畜健康造成严重危害。真菌毒素具有多种毒性作用,包括神经毒性、肝毒性、免疫毒性、致畸性和致癌性等,但其免疫毒性机制尚不完全清楚。树突状细胞(DCs)作为功能最强大的抗原提呈细胞,在启动先天免疫和获得性免疫应答中发挥重要作用。现有研究发现真菌毒素能够影响DCs的内吞作用、刺激T细胞活化的能力以及细胞因子和趋化因子的分泌,本文旨在综述真菌毒素对DCs免疫应答的影响,为后续研究阐明真菌毒素的免疫毒性机制提供参考。Mycotoxins are secondary metabolites produced by pathogenic fungi.They often contaminate various crops,and are detrimental to human and animal health.Mycotoxins have a variety of toxic effects,such as neurotoxicity,hepatotoxicity,immunotoxicity,teratogenicity,and carcinogenicity.However,the mechanism of immunotoxicity is still unclear.Dendritic cells(DCs),as the most potent antigen presenting cells,play a vital role in initiating innate and adaptive immune responses.Previous studies have found that mycotoxins can affect the endocytosis of DCs,the ability to stimulate T cell activation,the secretion of cytokines and chemokines.Thus,this review is aim to summarize the effects of mycotoxins on DCs-mediated immune responses,which may provide reference for researches to clarify the immunotoxicity mechanism of mycotoxins.

关 键 词：真菌毒素 免疫毒性 树突状细胞 抗原提呈细胞 

分 类 号：R392[医药卫生—免疫学]