髓源抑制性细胞与肝癌  

Myeloid-derived suppressor cells and hepatocellular carcinoma

作　　者：刘峻池 李艳茹[1] LIU Junchi;LI Yanru(Key Laboratory of Pathobiology,Ministry of Education,Jilin University,Changchun 130021,China;The First Clinical College of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学病理生物学教育部重点实验室,长春130021 [2]吉林大学第一临床医学院,长春130021

出　　处：《中国免疫学杂志》2024年第4期880-887,共8页Chinese Journal of Immunology

基　　金：吉林省卫生技术创新项目(2017J057)。

摘　　要：髓源抑制性细胞(MDSCs)作为肿瘤免疫微环境中的一种异质性细胞群,可在肿瘤患者和荷瘤动物体内大量扩增及聚集,并发挥免疫抑制活性。近年来的一些研究表明,MDSCs在肝癌的发生、发展和转移过程中也发挥重要作用。本文将综述MDSCs与肝癌的相关研究进展,探讨其在肝癌中的作用及潜在治疗策略。Myeloid-derived suppressor cells(MDSCs)are a heterogeneous cell population in tumor immune microenvironment that can undergo amplification and aggregation in tumor patients and tumor-bearing animals,exerting immunosuppressive activities.Recent studies have demonstrated the significant role of MDSCs in the occurrence,development and metastasis of liver cancer.This paper aims to review the research progress on MDSCs and hepatocellular carcinoma,exploring their involvement in hepatocellular carcinoma as well as potential therapeutic strategies.

关 键 词：髓源抑制性细胞 肝癌 免疫抑制 免疫疗法 

分 类 号：R730.2[医药卫生—肿瘤]