CCT5在卵巢浆液性囊腺癌组织中的表达及临床意义  

The expression and clinical significance of CCT5 in ovarian serous cystadenoma

作　　者：王瑀璇 胡悦欣 刘鸥萱 李馨如 曾凯 范相成 李潇[1,2] 林蓓 WANG Yuxuan;HU Yuexin;LIU Ouxuan;LI Xinru;ZENG Kai;FAN Xiangcheng;LI Xiao;LIN Bei(Department of Gynecology and Obstetrics,Shengjing Hosipital Affiliated to China Medical University,Liaoning Shenyang 110004,China;Key Laboratory of Maternal Fetal Medicine of Liaoning Province,Key Laboratory of Obstetrics and Gynecology of Higher Education of Liaoning Province,Liaoning Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004 [2]辽宁省母胎医学重点实验室,辽宁省高校妇产科重点实验室,辽宁沈阳110004

出　　处：《现代肿瘤医学》2024年第10期1893-1897,共5页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:82173130);辽宁省沈阳市科学技术计划(编号:22-315-6-16,22-321-33-19);盛京自由研究者计划(编号:201804)。

摘　　要：目的:探讨CCT5在卵巢浆液性囊腺癌组织中的表达及其与卵巢癌患者临床病理参数和预后的相关性。方法:利用免疫组织化学染色法检测CCT5在50例卵巢浆液性囊腺癌组织、22例卵巢交界性肿瘤组织、25例卵巢上皮性良性肿瘤组织以及9例正常卵巢组织中的表达情况,分析其与卵巢癌患者临床病理参数及预后的相关性。结果:CCT5以细胞浆着色为主。CCT5在卵巢浆液性囊腺癌中的阳性和强阳性表达率(88.0%&72.0%)明显高于良性组(64.0%&28.0%)和正常卵巢组织(66.7%&22.2%)。在卵巢浆液性囊腺癌中,CCT5表达与患者年龄、FIGO分期、肿瘤分化程度和淋巴结转移均无显著相关性(P>0.05)。CCT5表达影响卵巢浆液性囊腺癌患者总生存时间,是影响患者预后的独立危险因素(P<0.05)。结论:CCT5在卵巢浆液性囊腺癌组织中高表达且与患者预后密切相关,有望成为肿瘤筛查和诊断的新型标志物和临床治疗的潜在靶点。Objective:To investigate the expression of CCT5 in ovarian serous cystadenoma tissues and its correlation with clinical-pathological parameters and prognosis of ovarian cancer patients.Methods:Immunohistochemical staining was used to evaluate the expression of CCT5 in 50 cases of ovarian serous cystadenoma tissues,22 cases of ovarian borderline tumor tissues,25 cases of ovarian epithelial benign tumor tissues,and 9 cases of normal ovarian tissues.The correlation between CCT5 expression and clinical-pathological parameters and prognosis of ovarian cancer patients was analyzed.Results:CCT5 mainly exhibited cytoplasmic staining.The positive and strongly positive expression rates of CCT5 in ovarian serous cystadenoma tissues(88.0%&72.0%)were significantly higher than those in the benign group(64.0%&28.0%)and normal ovarian tissues(66.7%&22.2%).In ovarian serous cystadenoma tissues,CCT5 expression showed no significant correlation with patients'age,FIGO stage,tumor differentiation,and lymph node metastasis(P>0.05).CCT5 expression significantly influenced the overall survival time of the ovarian serous cystadenoma patients and was identified as an independent risk factor for patient prognosis(P<0.05).Conclusion:CCT5 is highly expressed in ovarian serous cystadenoma tissues and is closely correlated with patient prognosis,making it a potential novel biomarker for tumor screening and diagnosis,as well as a promising target for clinical treatment.

关 键 词：CCT5 卵巢浆液性囊腺癌 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]