醋酸甲羟孕酮联合化疗治疗子宫内膜癌术后患者的临床疗效  

Clinical efficacy of medroxyprogesterone acetate combined with chemotherapy in the treatment of patients with endometrial carcinoma after surgery

作　　者：李鹏程 熊丽丽[1] 沈乾坤 丁勇哲 LI Pengcheng;XIONG Lili;SHEN Qiankun;DING Yongzhe(Department of Gynecology,the First Affiliated Hospital of He’nan University of Science and Technology,Luoyang 471000,He’nan,China;Department of Clinical Medicine,School of Basic Medicine,He’nan University of Science and Technology,Luoyang 471000,He’nan,China)

机构地区：[1]河南科技大学第一附属医院妇科,河南洛阳471000 [2]河南科技大学基础医学院临床医学系,河南洛阳4710000

出　　处：《癌症进展》2024年第5期554-558,共5页Oncology Progress

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200591)。

摘　　要：目的探讨醋酸甲羟孕酮联合化疗治疗子宫内膜癌术后患者的临床疗效。方法根据腹腔镜手术后治疗方法的不同将98例子宫内膜癌患者分为对照组(n=49,单纯化疗)和观察组(n=49,醋酸甲羟孕酮联合化疗)。比较两组患者的肿瘤标志物[肿瘤特异性生长因子(TSGF)、X连锁凋亡抑制蛋白(XIAP)、肿瘤坏死因子-α(TNF-α)]水平、性激素[雌二醇(E_(2))、睾酮(T)、卵泡刺激素(FSH)、黄体生成素(LH)、催乳素(PRL)、性激素结合球蛋白(SHBG)]水平、生活质量[欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30)]、不良反应发生情况、复发率及复发间隔时间。结果治疗后,两组患者TSGF、XIAP、TNF-α、E_(2)水平均低于本组治疗前,观察组患者TSGF、XIAP、TNF-α、E_(2)水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者认知功能、躯体功能、情绪功能、社会功能评分均高于本组治疗前,观察组患者认知功能、躯体功能、情绪功能、社会功能评分均高于对照组,差异均有统计学意义(P<0.05)。两组患者骨髓抑制、胃肠道反应、肝肾功能异常发生率比较,差异均无统计学意义(P>0.05)。随访6个月,观察组患者的复发率低于对照组,复发间隔时间长于对照组,差异均有统计学意义(P<0.05)。结论醋酸甲羟孕酮联合化疗治疗子宫内膜癌术后患者的临床疗效较好,可降低肿瘤标志物水平和复发率,提高生活质量,且安全性较好。Objective To explore the clinical efficacy of medroxyprogesterone acetate combined with chemotherapy in the treatment of patients with endometrial carcinoma after surgery.Method A total of 98 patients with endometrial carcinoma were divided into control group(n=49,chemotherapy alone)and observation group(n=49,medroxyprogesterone acetate combined with chemotherapy)according to the different treatment methods after laparoscopic surgery.The tumor markers[tumor specific growth factor(TSGF),X-linked inhibitor of apoptosis(XIAP),tumor necrosis factor-α(TNF-α)]levels,sex hormones[estradiol(E_(2)),testosterone(T),follicle stimulating hormone(FSH),luteinizing hormone(LH),prolactin(PRL)and sex hormone-binding globulin(SHBG)]levels,quality of life[European Organization for Research and Treatment of Cancer quality of life questionnaire core 30(EORTC QLQ-C30)],adverse reactions,recurrence rate and recurrence interval were compared between the two groups.Result After treatment,the TSGF,XIAP,TNF-αand E_(2) levels in both groups were lower than those before treatment,and the TSGF,XIAP,TNF-αand E_(2) levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of cognitive function,physical function,emotional function and social function in both groups were higher than those before treatment,and the scores of cognitive function,physical function,emotional function and social function in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the incidence of myelosuppression,gastrointestinal reaction and abnormal liver and kidney function between the two groups(P>0.05).After 6 months of follow-up,the recurrence rate of the observation group was lower than that of the control group,and the recurrence interval was longer than that of the control group,and the differences were statistically significant(P<0.05).Conclusion M

关 键 词：子宫内膜癌 醋酸甲羟孕酮 化疗 肿瘤标志物 生活质量 复发 

分 类 号：R737.33[医药卫生—肿瘤]