驱动蛋白家族成员26B在膀胱癌中的表达及与临床病理特征、预后的关系  

Expression of Kinesin Family Member 26B in Bladder Cancer and its Relationship with Clinicopathological Features and Prognosis

作　　者：卢保德 龙贤 黄勇平[1] LU Bao-de;LONG Xian;HUANG Yong-ping(Department of Urology,Affliated Hospital of Youjiang University for Nationalities,Baise 533000,Guangxi,China)

机构地区：[1]右江民族医学院附属医院泌尿外科,广西百色533000

出　　处：《医学信息》2024年第9期107-111,共5页Journal of Medical Information

基　　金：百色市科学研究与技术开发计划(编号:百科20213719);右江民族医学院高层次人才科研项目(编号:R20196337);右江民族医学院校级课题(编号:yy2019ky010)。

摘　　要：目的探讨驱动蛋白家族成员26B(KIF26B)在膀胱癌中的表达与临床病理特征及预后的关系。方法从TCGA数据库下载膀胱癌RNA表达谱及临床数据,用R语言相关数据包分析KIF26B在膀胱癌中的表达水平及与临床病理、预后的关系。收集2019年5月-2021年6月在右江民族医学院附属医院接受手术治疗的60例膀胱癌及癌旁组织样本,采用qRT-PCR检测KIF26B在膀胱癌组织中的表达水平,分析KIF26B表达与临床病理特征的关系。结果TCGA数据库中,膀胱癌组织KIF26B表达高于癌旁正常组织(P<0.05),且KIF26B表达与膀胱癌的病理类型、肿瘤分级、T分期、AJCC分期有关(P<0.05),与性别、年龄、肿瘤N分期、M分期无关(P>0.05);KIF26B高表达患者肿瘤特异性生存期和总生存期均低于KIF26B低表达者(P<0.05)。60例膀胱癌组织中,膀胱癌组织KIF26B表达高于癌旁正常组织(P<0.05),且KIF26B表达与膀胱癌肿瘤分级、T分期、N分期、和吸烟有关(P<0.05),与性别、年龄、M分期无关(P>0.05)。结论KIF26B在膀胱癌中高表达,与膀胱癌的临床病理特征及预后相关。Objective To investigate the expression of kinesin family member 26B(KIF26B)in bladder cancer and its relationship with clinicopathological features and prognosis.Methods The RNA expression profile and clinical data of bladder cancer were downloaded from the TCGA database.The expression level of KIF26 B in bladder cancer and its relationship with clinicopathology and prognosis were analyzed by R language related data package.From May 2019 to June 2021,60 cases of bladder cancer and adjacent tssue samples were collected from the Affiliated Hospital of Youjiang University for Nationalities.The expression level of KIF26B in bladder cancer tissues was detected by qRT-PCR,and the relationship between KIF26B expression and clinicopathological features was analyzed.Results In TCGA database,the expression of KIF26B in bladder cancer tissues was higher than that in adjacent normal tissues(P<0.05),and the expression of KIF26B was related to the pathological type,tumor grade,T stage and AJCC stage of bladder cancer(P<0.05),but not to gender,age,tumor N stage and M stage(P>0.05);the tumor-specific survival and overall survival of patients with high KIF26B expression were lower than those with low KIF26B expression(P<0.05).In 60 cases of bladder cancer tissues,the expression of KIF26B in bladder cancer tissues was higher than that in adjacent normal tissues(P<0.05),and the expression of KIF26B was related to tumor grade,T stage,N stage and smoking(P<0.05),but not to gender,age and M stage(P>0.05).Conclusion KIF26B is highly expressed in bladder cancer and is related to the clinicopathological features and prognosis of bladder cancer.

关 键 词：膀胱癌 驱动蛋白家族成员26B 临床病理特征 

分 类 号：R737.14[医药卫生—肿瘤]