5-HTR1A基因rs6295多态性与抑郁症伴自伤行为的相关研究  

Related Research on rs6295 Polymorphism of 5-HTR1A Gene and Depression with Self-injury Behavior

作　　者：郁德波 林志雄 林举达 YU De-bo;LIN Zhi-xiong;LIN Ju-da(The First Clinical College of Medicine,Guangdong Medical University,Zhanjiang 524001,Guangdong,China;Department of Psychiatry,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,Guangdong,China)

机构地区：[1]广东医科大学第一临床医学院,广东湛江524001 [2]广东医科大学附属医院精神心理科,广东湛江524001

出　　处：《医学信息》2024年第9期179-183,共5页Journal of Medical Information

摘　　要：抑郁症是一种高发病率的慢性疾病,然而对抑郁症的病因及发病机制的了解仍然不足,其强大的遗传能力和遗传基础已从家庭、双胞胎和收养研究中得到很好的证实,5-HTR1A启动子的rs6295多态性与抑郁症伴自伤行为有关。本文就5-HTR1A基因rs6295多态性与抑郁症伴自伤行为之间的发病机制、研究现况和治疗进展进行综述,以期为预测抑郁障碍伴NSSI的遗传易感性提供参考依据。Depression is a chronic disease with high incidence.However,the etiology and pathogenesis of depression are still poorly understood.Its strong genetic ability and genetic basis have been well confirmed by family,twin and adoption studies,suggesting that rs6295 polymorphism of 5-HTR1A promoter is associated with depression with self-injury behavior.This article reviews the pathogenesis,research status and treatment progress of rs6295 polymorphism of 5-HTR1A gene and depression with self-injury behavior,in order to provide a reference for predicting the genetic susceptibility of depression with NSSI.

关 键 词：人5-羟色胺受体1A 抑郁症 自伤行为 基因多态性 

分 类 号：R749.41[医药卫生—神经病学与精神病学]