结直肠侧向发育型肿瘤的癌变及筛查研究现状  

Research Status of Canceration and Screening of Colorectal Laterally Spreading Tumors

作　　者：古再奴尔·艾买尔江 古丽巴哈尔·司马义[1] Guzainu’er·Aimai’erjiang;Gulibaha’er·Simayi(The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学第一附属医院,新疆乌鲁木齐830011

出　　处：《中外医学研究》2024年第12期173-178,共6页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：结直肠侧向发育型肿瘤(colorectal laterally spreading tumor,CLST)是起源于结直肠黏膜,直径≥10 mm的一类平坦隆起型病变,以侧向发育为主要特征,与结直肠其他隆起性腺瘤相比,CLST具有不同的形态学特征、特殊的生长方式及更高的恶性潜能,被认为与结直肠癌的发生发展密切相关。现有共识是,大规模早期筛查、早诊断、早治疗是防控结直肠癌及CLST癌变的关键。CLST的癌变过程涉及多种分子机制,近年来,随着内镜设备的更新、各种辅助技术的发展,以及内镜医师对CLST的认识增强,CLST检出率较前增加。现对CLST癌变及筛查研究现状做一综述。Colorectal laterally spreading tumor(CLST)is a kind of flat protuberant lesion originating from colorectal mucosa with a diameter≥10 mm,it is mainly characterized by lateral development.Compared with other colorectal protuberant adenomas,CLST has different morphological characteristics,special growth mode and higher malignant potential,it is considered to be closely related to the occurrence and development of colorectal cancer.The current consensus is that large-scale early screening,early diagnosis and early treatment are the key to the prevention and control of colorectal cancer and CLST carcinogenesis.The carcinogenesis process of CLST involves a variety of molecular mechanisms.In recent years,with the update of endoscopic equipment,the development of various auxiliary technologies,and the enhancement of endoscopic physicians'understanding of CLST,the detection rate of CLST has increased.This article reviewed the research status of CLST carcinogenesis and screening.

关 键 词：侧向发育型肿瘤 结直肠癌 癌变特征 癌变机制 筛查 

分 类 号：R735.34[医药卫生—肿瘤]