β-2微球蛋白、NLR与tPSA对高PSA的前列腺癌患者的诊断价值  

Diagnostic Value of β-2 Microglobulin,Neutrophil-to-Lymphocyte Ratio and Total Prostate Specific Antigen in Prostate Cancer Patients with Elevated PSA

作　　者：王晨 刘奔 WANG Chen;LIU Ben(Department of Urology,Jinzhou Central Hospital Postgraduate Training Base,Jinzhou 121001,China;Department of Urology,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China)

机构地区：[1]锦州医科大学锦州市中心医院研究生培养基地泌尿外科,辽宁锦州121001 [2]锦州医科大学附属第一医院泌尿外科,辽宁锦州121001

出　　处：《实用临床医学（江西）》2024年第2期32-36,49,共6页Practical Clinical Medicine

基　　金：锦州医科大学研究生科研基金。

摘　　要：目的探究β-2微球蛋白(β-2 MG)、中性粒细胞与淋巴细胞比值(NLR)与总前列腺特异性抗原(tPSA)对前列腺特异性抗原(PSA)升高的前列腺癌(PCa)患者的诊断价值。方法选取2020年5月至2023年12月行前列腺穿刺活检或行经尿道前列腺电切术(TURP)后,且tPSA>4 ng·mL^(-1)的患者210例。根据病理结果将其分为良性前列腺增生(BPH)组(n=110)及PCa组(n=100),采用Logistic回归、ROC曲线分析评价单一和(或)多指标联合诊断高PSA人群中PCa的效能。结果PCa组tPSA、游离性前列腺特异性抗原、中性粒细胞、β-2 MG、NLR水平高于BPH组(P<0.05);PCa组前列腺体积、淋巴细胞水平低于BPH组(P<0.05)。tPSA、β-2 MG和NLR是PCa发病的独立危险因素,且这三者联合均高于单一指标、两两指标联合的诊断效能。结论tPSA+β-2-MG+NLR联合预测的诊断模型效能较高,可早期预测PSA升高患者是否患有PCa。Objective To investigate the diagnostic value ofβ-2 microglobulin(beta-2 MG),neutrophil-to-lymphocyte ratio(NLR),and total prostate-specific antigen(tPSA)in prostate cancer(PCa)patients with elevated prostate-specific antigen(PSA).Methods 210 patients who underwent prostate biopsy or transurethral resection of the prostate by electrocautery(TURP)from May 2020 to December 2023 and had a tPSA level over 4 ng·mL^(-1)were chosen and divided into benign prostatic hyperplasis(BPH)group(n=110)and PCa group(n=100)according to the pathologic diagnosis.Logistic regression and ROC curve analysis were used to evaluate the diagnosis value of single and/or multiple indicators in PCa from patients with high PSA.Results The levels of tPSA,free prostate-specific antigen,neutrophils,β-2 MG,and NLR were higher in the PCa group than in the BPH group(P<0.05);prostate volume and lymphocyte levels were lower in the PCa group than in the BPH group(P<0.05).tPSA,β-2 MG and NLR were independent risk factors for the development of PCa and the diagnosis efficiency of the combined detection of those three factors was higher than that of single factor and of pairwise factors.Conclusion High diagnostic value could be observed in the combined detection of tPSA,β-2 MG and NLR,which suggests that it might allow early diagnosis of whether a patient with elevated PSA has PCa.

关 键 词：前列腺癌 良性前列腺增生 Β-2微球蛋白 中性粒细胞与淋巴细胞比值 前列腺特异性抗原 诊断 

分 类 号：R737.25[医药卫生—肿瘤]