COL1A1、KPNA2在三阴性乳腺癌组织中的表达及与远期预后的关系  

Expressions of COL1A1 and KPNA2 in triple-negative breast cancer tissues and their relationship with long-term prognosis

作　　者：廖登辉[1] 王婷[1] 甘霖[1] 闵杰 王亚东 曾真[1] 吕钢[1] LIAO Denghui;WANG Ting;GAN Lin;MIN Jie;WANG Yadong;ZENG Zhen;LYU Gang(Department of Breast,Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400021,China)

机构地区：[1]重庆市中医院乳腺科,重庆400021

出　　处：《西部医学》2024年第5期713-718,共6页Medical Journal of West China

基　　金：2021年重庆市科研机构绩效激励引导专项项目(jxyn-2021-2-29)。

摘　　要：目的探讨Ⅰ型胶原蛋白α1链(COL1A1)、核转运蛋白α2(KPNA2)在三阴性乳腺癌(TNBC)组织中的表达及与远期预后的关系。方法收集2016年6月—2017年6月本院收治的87例TNBC患者为研究对象,患者均经手术留取癌组织及癌旁组织标本,采用免疫组织化学法检测COL1A1、KPNA2在各组织标本中的表达情况,分析两者表达情况与患者病理特征的关系,绘制生存曲线分析二者表达情况与患者5年预后的关系,采用COX回归模型分析影响患者预后生存的因素。结果COL1A1、KPNA2在TNBC患者癌组织中高表达率显著高于癌旁组织(P<0.05)。在TNBC癌组织中,COL1A1、KPNA2高表达与组织学分级、脉管侵犯、淋巴结转移情况有关(P<0.05),COL1A1高表达还与临床分期有关(P<0.05)。随访5年,87例患者总生存率78.16%(68/87),COL1A1高表达者生存期较低表达者更短(P<0.05),KPNA2高表达者较低表达者生存期更短(P<0.05)。COX回归分析显示,临床分期Ⅲ期、有淋巴结转移、COL1A1高表达、KPNA2高表达是三阴性乳腺癌患者预后生存的影响因素(P<0.05)。结论COL1A1、KPNA2在TNBC患者癌组织中表达均增加,两者高表达与患者组织学分级、脉管侵犯、淋巴结转移情况均有关,且影响患者远期预后。Objective To explore the expressions of collagen type Iα1 chain(COL1A1)and karyopherinα2(KPNA2)in triple-negative breast cancer(TNBC)tissues and their relationship with long-term prognosis.Methods A total of 87 patients with TNBC who were treated in the hospital from June 2016 to June 2017 were collected as the research subjects.The cancer tissue and adjacent tissue samples were collected from the patients after surgery,and immunohistochemistry was used to detect the expressions of COL1A1 and KPNA2 in the tissue samples,and the relationship between the expressions of the two and the pathological characteristics of patients was analyzed.Survival curve was drawn to analyze the relationship between the expressions of the two and the 5-year prognosis of patients.COX regression model was adopted to analyze the factors affecting the prognosis survival of patients.Results The high expression rates of COL1A1 and KPNA2 in TNBC cancer tissues were significantly higher than those in adjacent tissues(P<0.05).In TNBC cancer tissues,the high expressions of COL1A1 and KPNA2 were related to histological grading,vascular invasion and lymph node metastasis(P<0.05),and the high expression of COL1A1 was also related to clinical staging(P<0.05).After 5 years of follow-up,the overall survival rate of 87 patients was 78.16%(68/87),and the patients with high COL1A1 expression had a shorter survival time(P<0.05),and those with high KPNA2 expression had a shorter survival time than those with lower KPNA2 expression(P<0.05).COX regression analysis showed that clinical stageⅢ,presence of lymph node metastasis,high expression of COL1A1 and high expression of KPNA2 were the influencing factors for prognosis survival of patients with triple-negative breast cancer(P<0.05).Conclusion The expressions of COL1A1 and KPNA2 are increased in the cancer tissues of patients with TNBC,and their high expressions are related to the histological grading,vascular invasion and lymph node metastasis of patients,and can affect the long-term prognosis of pat

关 键 词：三阴性乳腺癌 Ⅰ型胶原蛋白α1链 核转运蛋白基因2 远期预后 

分 类 号：R737.9[医药卫生—肿瘤]