HER-2阴性乳腺癌合并腋窝淋巴结转移新辅助化疗肿瘤退缩模式的影响因素  

Analysis of influencing factors of tumor regression pattern of neoadjuvant chemotherapy in HER2-negative breast cancer with axillary lymph node metastasis

作　　者：马金平 曹伟红[2] 张佳凤 方圣 张剑 张家宏 王腾 马源 张勇 MA Jinping;CAO Weihong;ZHANG Jiafeng;FANG Sheng;ZHANG Jian;ZHANG Jiahong;WANG Teng;MA Yuan;ZHANG Yong(Department of General Surgery,Yantai Penglai People's Hospital,Yantai 265600,Shandong,China;Breast Diagnosis and Treatment Center,The Affiliated Hospital of Medical College of Qingdao University,Qingdao 266000,Shandong,China;Department of General Surgery,Jiaozhou Traditional Chinese Medicine Hospital,Jiaozhou 266300,Shandong,China)

机构地区：[1]烟台市蓬莱人民医院普外一科,山东烟台265600 [2]青岛大学医学院附属医院乳腺病诊疗中心,山东青岛266000 [3]胶州市中医医院普外科,山东青岛266300

出　　处：《西部医学》2024年第5期723-727,共5页Medical Journal of West China

基　　金：青岛大学医疗集团科研专项项目(YLJT20202020)。

摘　　要：目的了解人表皮生长因子受体-2(HER-2)阴性乳腺癌合并腋窝淋巴结转移的肿瘤退缩模式并分析其影响因素。方法回顾性分析青岛大学医学院附属医院乳腺病诊疗中心2017年7月—2021年7月诊治的129例HER2阴性乳腺癌合并腋窝淋巴结转移病例,分析肿瘤退缩模式的影响因素。单因素、多因素分析分别采用χ^(2)检验、二元回归分析。结果HER2阴性、腋窝淋巴结转移乳腺癌,向心性退缩占62.02%,非向心性退缩占37.98%。单因素和多因素分析均显示,肿瘤分期与退缩模式差异有统计学意义(P<0.05)。结论原发肿瘤越大、浸润程度越深,非向心性退缩可能性越大。临床中对于cT4的原发肿瘤,新辅助治疗后选择保乳手术应慎重。Objective To investigate the tumor regression pattern of human epidermal growth factor receptor 2(HER2)negative breast cancer with axillary lymph node metastasis and analyze its influencing factors.Methods A retrospective analysis was performed on 129 cases of HER2-negative breast cancer with axillary lymph node metastasis diagnosed and treated in the department of breast center of the Affiliated Hospital of Qingdao University from July 2017 to July 2021,and analyzed the influencing factors of tumor regression pattern.χ^(2) test was used for univariate analysis and binary regression was used for multivariate analysis.Results In HER2-negative breast cancer with axillary lymph node metastasis,62.02%of breast cancer patients had centralistic regression,37.98%had non-centralistic regression.Univariate and multivariate analysis showed that there were significant differences in tumor stage and regression mode(P<0.05).Conclusion The larger the primary tumor,the deeper the invasion,the greater the possibility of non-centripetal regression.In clinical practice,breast-conserving surgery should be carefully selected after neoadjuvant therapy for cT4 primary tumors.

关 键 词：HER2阴性 乳腺癌 腋窝淋巴结 新辅助化疗 肿瘤退缩模式 

分 类 号：R737.9[医药卫生—肿瘤]