肿瘤大剂量维生素C治疗专家共识(2024年)  

Expert consensus on high-dose vitamin C therapy for Cancer(2024)

作　　者：饶本强 王诗婉 石汉平 曲晋秀 路帅 王冰 何嘉 赵媛 唐华臻 王林 王欣 张展志 陈永兵 朱乾坤 张骁玮 中国抗癌协会营养治疗专业委员会 中国抗癌协会中西整合控瘤新药研究专业委员会 中国老年保健协会营养代谢分会 Rao Benqiang;Wang Shiwan;Shi Hanping;Qu Jinxiu;Lu Shuai;Wang Bing;He Jia;Zhao Yuan;Tang Huazhen;Wang Lin;Wang Xin;Zhang Zhanzhi;Chen Yongbing;Zhu Qiankun;Zhang Xiaowei;Chinese Society of Nutritional Oncology(CSNO);Specialized Committee of Chinese and Western Integrated Tumor Control Drugs of China Anti Cancer Association;Nutrition Metabolism Branch of Chinese Aging Well Association(Center for Oncology Nutrition and Metabolism,Beijing Shijitan Hospital,Capital Medical University/Key Laboratory of Cancer FSMP for State Market Regulation,Beijing 100038,China;Department of General Surgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;不详)

机构地区：[1]首都医科大学附属北京世纪坛医院肿瘤营养与代谢中心,国家肿瘤市场监管重点实验室,北京100038 [2]首都医科大学附属北京天坛医院普外科,北京100070 [3]不详

出　　处：《肿瘤代谢与营养电子杂志》2024年第2期181-186,共6页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：国家重点研发计划项目(2022YFC2009601)。

摘　　要：肿瘤大剂量维生素C(HDVC)治疗疗效并不稳定,需要精准强化治疗。然而,目前在全世界范围内缺乏肿瘤HDVC规范化治疗方案,对肿瘤HDVC精准强化治疗也缺乏共识,严重影响肿瘤HDVC治疗效果和临床应用。中国抗癌协会营养治疗专业委员会、中国抗癌协会中西整合控瘤新药研究专业委员会和中国老年保健协会营养代谢分会部分对肿瘤HDVC治疗具有较丰富经验的专家,对肿瘤HDVC治疗机制、HDVC药代动力学特征进行了深入讨论,并就肿瘤HDVC适应证和禁忌证、临床治疗优势方案、不良反应预防和治疗、敏感性精准治疗代谢分子表型、强化治疗策略和疗效监测等形成了共识。肿瘤HD-VC治疗专家共识将有助于提高肿瘤HDVC治疗规范化水平和疗效。The efficacy of high-dose vitamin C(HDVC)treatment for tumors is fragile and requires precise and intensified treatment.However,there is not only an absence of standardized therapeutic schedule of HDVC for cancers,but also a lack of high-quality guidelines for precise and intensive treatment of HDVC for tumors,which seriously affects the therapeutic effect and clinical application of HDVC.Based on in-depth discussions on the anti-tumor mechanisms and the pharmacokinetic characteristics of of HDVC,experts with rich experience in the Nutrition Therapy Professional Committee of China Anti-Cancer Association,the Research Committee of New Anti-Cancer Drugs for Chinese and Western Integrated Tumor Control and the Nutrition Metabolism Branch of China Elderly Care Association have reached a consensus on the indications and contraindications of HDVC,clinical advantage administration,the prevention and treatment of side effects,the sensitivity and precision treatment of metabolic molecular phenotype,the intensive treatment strategy and efficacy monitoring.This consensus will help improve the the standardization and efficacy of of high dose vitamin C treatment against cancer.

关 键 词：大剂量维生素C 肿瘤 治疗 专家共识 

分 类 号：R730.5[医药卫生—肿瘤] R459.3[医药卫生—临床医学]