同步推量调强放疗在鼻咽癌中的应用效果及对免疫功能的影响  

Effectiveness of Simultaneous Push Volume Intensity Modulated Radiotherapy in Nasopharyngeal Carcinoma and the Effect on Immune Function

作　　者：吴仁瑞[1] 汪琛[1] 刘超[1] WU Ren-rui;WANG Chen;LIU Chao(Oncology Department of Ganzhou City People's Hospital,Ganzhou 341000,Jiangxi Province,China)

机构地区：[1]江西省赣州市人民医院肿瘤科,江西赣州341000

出　　处：《罕少疾病杂志》2024年第5期30-32,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨同步推量调强放疗在鼻咽癌中的应用效果及对免疫功能的影响。方法选取2019年1月至2020年1月于江西省赣州市人民医院诊治治疗的94例鼻咽癌患者,使用随机数字表法将其分为观察组(同步推量调强放疗)和对照组(常规调强放疗),各47例。对比两组的近远期疗效、免疫功能指标、肿瘤细胞生长促进因子水平及毒副反应发生率。结果观察组的治疗总有效率高于对照组;2年无进展生存率及2年无远处转移生存率高于对照组,但差异相较无统计学意义(P>0.05)。治疗前,两组的CD3+、CD4+/CD8+、CD15+及CD56+水平相较差异不显著(P>0.05);治疗后,两组的各项指标水平均降低,但观察组高于对照组(P>0.05)。治疗前,两组的转化生长因子-β1(TGF-β1)和血管内皮生长因子(VEGF)水平相较差异不显著(P>0.05);治疗后,两组的两项指标水平均降低,观察组低于对照组(P<0.05)。观察组的毒副反应发生率低于对照组(P<0.05)。结论同步推量调强放疗治疗鼻咽癌,可提高近期疗效,减轻免疫功能损伤,降低肿瘤细胞生长促进因子水平,减少毒副反应,疗效显著,且安全性较高。Objective To explore the application effect of synchronized dose modulated radiotherapy in nasopharyngeal carcinoma and its impact on immune function.Method 94 nasopharyngeal carcinoma patients who were treated at Ganzhou People's Hospital in Jiangxi Province from January 2019 to January 2020 were selected.They were randomly divided into an observation group(synchronous intensity modulated radiation therapy)and a control group(conventional intensity modulated radiation therapy)using a random number table method,with 47 cases in each group.Compare the short-term and long-term therapeutic effects,immune function indicators,tumor cell growth promoting factor levels,and incidence of toxic side effects between the two groups.Result The total effective rate of treatment in the observation group was higher than that in the control group;The 2-year progression free survival rate and 2-year distant metastasis free survival rate were higher in the control group,but the difference was not statistically significant(P>0.05).Before treatment,there was no significant difference in the levels of CD3+,CD4+/CD8+,CD15+,and CD56+between the two groups(P>0.05);After treatment,the levels of various indicators in both groups decreased,but the observation group was higher than the control group(P>0.05).Before treatment,the transforming growth factors in both groups-β1(TGF-β1)There was no significant difference in the levels of vascular endothelial growth factor(VEGEG F)compared to the control group(P>0.05);After treatment,the levels of both indicators in both groups decreased,and the observation group was lower than the control group(P<0.05).The incidence of toxic side effects in the observation group was lower than that in the control group(P<0.05).Conclusion Synchronous dose modulated radiation therapy for nasopharyngeal carcinoma can improve short-term efficacy,reduce immune function damage,lower tumor cell growth promoting factor levels,reduce toxic side effects,and has significant therapeutic effects with high safety.

关 键 词：鼻咽癌 同步推量调强放疗 免疫功能 肿瘤细胞生长促进因子 毒副反应 

分 类 号：R73-3[医药卫生—肿瘤]