倍他司汀联合前庭功能康复训练对中重度持续性姿势-感知性头晕患者平衡功能的影响  

Effect of Betahistine Combined with Vestibular Rehabilitation Therapy on Balance Function in Patients with Moderate to Severe Persistent Postural-perceptual Dizziness

作　　者：刘晓东 王淑楠[1] 洪丽[1] LIU Xiao-dong;WANG Shu-nan;HONG Li(Department of Neurology Anyang Regional Hospital,Puyang City,Puyang 455000,Henan Province,China)

机构地区：[1]濮阳市安阳地区医院神经内科,河南安阳455000

出　　处：《罕少疾病杂志》2024年第5期108-109,121,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨倍他司汀联合前庭功能康复训练(VRT)对中重度持续性姿势-感知性头晕(PPPD)患者平衡功能的影响。方法将2021年5月~2023年5月期间于本院神经内科门诊医治的62例中重度PPPD患者,利用简单随机分组分为研究组(使用倍他司汀联合VRT治疗)和对照组(使用倍他司汀治疗),每组患者各31例,均持续治疗2个月。比较两组患者治疗效果、治疗前后前庭症状、平衡功能、眩晕程度及不良反应发生情况。结果治疗后,研究组患者治疗总有效率为90.32%,对照组治疗总有效率为67.74%,研究组治疗效果高于对照组,差异有统计学意义(P<0.05);治疗后,研究组患者前庭症状指数(VSI)评分较对照组低,Berg平衡量表(BBS)评分较对照组高,差异有统计学意义(P<0.05);治疗后,研究组患者眩晕程度(身躯、情感及功能)评分较对照组低,差异有统计学意义(P<0.05);治疗后,两组患者发生胃部不适、口干、头痛、皮肤瘙痒的情况比较,差异无统计学意义(P>0.05)。结论倍他司汀联合VRT能有效改善中重度PPPD患者平衡功能,减轻眩晕程度,具有良好的治疗效果。Objective To explore the effects of betahistine combined with vestibular rehabilitation therapy(VRT)on balance function in patients with moderate to severe persistent postural-perceptual dizziness(PPPD).Methods According to simple random grouping method,62 patients with moderate to severe PPPD treated in Neurology outpatient department of the hospital were divided into study group(betahistine+VRT)and control group(betahistine)between May 2021 and May 2023,31 cases in each group.All were treated for 2 months.The curative effect,vestibular symptoms,balance function,dizziness degree and occurrence of adverse reactions were compared between the two groups before and after treatment.Results After treatment,total response rate of treatment in study group was higher than that in control group(90.32%vs 67.74%,P<0.05).After treatment,score of vestibular symptom index(VSI)in study group was lower than that in control group,and score of Berg balance scale(BBS)was higher than that in control group(P<0.05).After treatment,scores of vertigo dizziness(body,emotion,function)in study group were lower than those in control group(P<0.05).After treatment,there was no significant difference in occurrence of adverse reactions(stomach discomfort,dry mouth,headache,skin pruritus)between the two groups(P>0.05).Conclusion Betahistine combined with VRT can effectively improve balance function and relieve dizziness in patients with moderate to severe PPPD,with good curative effect.

关 键 词：倍他司汀 前庭功能康复训练 中重度持续性姿势-感知性头晕 平衡功能 

分 类 号：R730.9[医药卫生—肿瘤]