替吉奥联合胃肿瘤血管介入栓塞治疗中老年晚期胃癌的临床研究  

Clinical Study on Combination of Tegio and Gastric Tumor Vascular in tervention Embolization in Treatment of Advanced Gastric Cancer of Middle-Aged and Elderly Patients

作　　者：李书有 聂荣军 苏凤婵 韦志松 韦晓娜 LI Shuyou;NIE Rongjun;SU Fengchan;WEI Zhisong;WEI Xiaona(Department of Oncology,Guangxi Medical University Affiliated Wuming Hospital,Nanning,Guangxi 530199)

机构地区：[1]广西医科大学附属武鸣医院肿瘤科,广西南宁530199

出　　处：《智慧健康》2024年第3期184-187,192,共5页Smart Healthcare

基　　金：广西壮族自治区卫生健康委员会自筹项目《替吉奥联合胃肿瘤血管介入栓塞治疗中老年晚期胃癌的临床研究》(Z20190268)。

摘　　要：目的 探讨替吉奥联合胃肿瘤血管介入栓塞治疗中老年晚期胃癌的临床效果。方法 选取2019年7月—2023年3月广西医科大学附属武鸣医院肿瘤科接收的60例中老年晚期胃癌患者,按数字随机表法分作两组,予以对照组(30例)口服单药替吉奥治疗,予以观察组(30例)替吉奥联合胃肿瘤血管介入栓塞治疗。比较两组患者的血清肿瘤标志物、临床疗效、生存质量及不良反应发生情况。结果 观察组治疗后癌胚抗原(CEA)、糖类抗原125(CA12-5)水平比对照组低(P<0.05);观察组疾病控制率比对照组高(P<0.05);观察组生存质量改善率比对照组高(P<0.05);两组不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论 替吉奥联合胃肿瘤血管介入栓塞治疗中老年晚期胃癌与单药替吉奥治疗对比,疗效显著,同时可降低血清肿瘤标志物,提升疾病控制率,并进一步改善患者生存质量,且安全性理想。Objective To explore clinical effect of combination therapy with gastric tumor vascular intervention and embolization in treatment of advanced gastric cancer of middle-aged and elderly patients.Methods The paper chose 60 middle-aged and elderly patients with advanced gastric cancer admitted to Oncology Department of Guangxi Medical University Affiliated Wuming Hospital from July 2019 to March 2023,and divided them into two groups with digital random table method.30 cases in control group were treated with oral monotherapy of Tegio,while 30 cases in observation group with Tegio combined with gastric tumor vascular intervention embolization.Serum tumor markers,clinical effect,life quality,and incidence of adverse reactions were compared between two groups.Results Levels of carcinoembryonic antigen(CEA) and carbohydrate antigen 125(CA12-5)in observation group were lower than control group after treatment(P<0.05).Disease control rate in observation group was 96.67%,higher than 73.33% in control group(P< 0.05).Improvement rate of life quality in observation group was 90.00%,higher than 66.67% in control group(P<0.05).There was no statistically significant difference in incidence of adverse reactions between two groups(P>0.05).Conclusion Combination of Tegio and gastric tumor vascular intervention embolization can achieve significantly better effect for advanced gastric cancer of middle-aged and elderly patients than monotherapy Tegio.At the same time,it can reduce serum tumor markers,improve disease control rate,and improve life quality of patients further,with ideal safety.

关 键 词：替吉奥 胃肿瘤血管介入栓塞 晚期胃癌 治疗 疗效 

分 类 号：R735.2[医药卫生—肿瘤]