活体激光共聚焦显微镜观察蠕形螨感染与麦粒肿关系的临床研究  

Clinical Study on the Relationship between Demodex Infection and Stele by Laser Confocal Microscopy in Vivo

作　　者：高峰 陈岩 潘淑玲 王小丽 GAO Feng;CHEN Yan;PAN Shuling;WANG Xiaoli(C-MER(Shanghai)Vision Eye Hospital,Shanghai 200000;Shanghai Aier Eye Hospital,Shanghai 200000)

机构地区：[1]上海希玛瑞视眼科医院,上海200000 [2]上海爱尔眼科医院,上海200000

出　　处：《智慧健康》2024年第4期46-49,共4页Smart Healthcare

摘　　要：目的 采用活体激光共聚焦显微镜(IVCM)观察麦粒肿和霰粒肿患者眼部蠕形螨感染情况,为分析蠕形螨感染对麦粒肿发生的影响提供参考依据。方法 选取2022年6—12月在上海爱尔眼科医院就诊为霰粒肿的患者45例(45眼)称霰粒肿组及无霰粒肿史的麦粒肿患者45例(45眼)称麦粒肿组。每位患者采取活体激光共聚焦显微镜观察患眼睑缘蠕形螨感染情况,上下睑缘选取累及所在位置8个毛囊、8个睑板腺。以蠕形螨检出≥3只为阳性、1≤蠕形螨<3只为可疑阳性、未检出为阴性。结果 活体激光共聚焦显微镜下,麦粒肿组和霰粒肿组蠕形螨感染阳性率分别为73.30%(33眼)、44.44%(20眼),可疑阳性率为31.11%(14眼)、11.10%(5眼),阴性率为15.60%(7眼)、24.44%(11眼);麦粒肿组阳性感染率明显高于霰粒肿组,差异具有统计学意义(P=0.013)。结论 与霰粒肿患者相比,麦粒肿患者的蠕形螨感染率更高,蠕形螨感染可能亦是麦粒肿发生的致病因素之一。Objective In vivo confocal laser microscope(IVCM)was used to observe the ocular demodex infection in patients with stye and chalazion,so as to provide reference for analyzing the influence of demodex infection on the occurrence of stye.Methods A total of 45 patients(45 eyes)who received treatment in Shanghai Aier Eye Hospital from June to December 2022 were selected as the stye group and 45 patients(45 eyes)with no history of chalazion were selected as the chalazion group.In vivo confocal laser microscopy(IVCM)was used to observe the infection of demodex in the eyelid margin of each patient,and 8 hair follicles and 8 meibomian glands in the upper and lower eyelid margin were selected for observation.≥3 cases of demodex were positive,1≤demodex<3 was suspected positive,and no demodex was negative.Results Under in vivo laser confocal microscopy,the positive rates of demodex infection were 73.30%(33 eyes)and 44.44%(20 eyes)in stye group and chalazion group,respectively.The suspected positive rates were 31.11%(14 eyes)and 11.10%(5 eyes),and the negative rates were 15.60%(7 eyes)and 24.44%(11 eyes);The rate of positive infection in the stye group was significantly higher than that in the chalazion group,the difference was statistically significant(P=0.013).Conclusion Compared with chalazion,the infection rate of demodex is higher in the patients with stye,and demodex infection may also be one of the pathogenic factors or the occurrence of stye.

关 键 词：蠕形螨 活体激光共聚焦显微镜(IVCM) 麦粒肿 霰粒肿 

分 类 号：R777.1[医药卫生—眼科]