兰索拉唑与泮托拉唑治疗急性非静脉曲张上消化道出血疗效差异分析  

Difference Between Lansoprazole and Pantoprazole in the Treatment of Acute Non-varicose Upper Gastrointestinal Bleeding

作　　者：汤亚君 TANG Yajun(Department of Gastroenterology,Zhangjiagang Aoyang Hospital,Suzhou Jiangsu 215600)

机构地区：[1]张家港澳洋医院消化内科,江苏苏州215600

出　　处：《智慧健康》2024年第4期132-135,共4页Smart Healthcare

摘　　要：目的 对比分析兰索拉唑与泮托拉唑治疗急性非静脉曲张上消化道出血疗效差异,以期从中遴选出一种更加安全高效的药物治疗方案。方法 选择2020年1月—2023年1月本院收治的60例急性非静脉曲张上消化道出血患者作为观察对象,设计前瞻对照试验,对患者进行编号,依据奇偶数将患者分为A组(奇数)和B组(偶数),每组30例,分别给予两组患者泮托拉唑和兰索拉唑进行治疗。结果 B组患者临床治疗总有效率优于A组(P<0.05);B组患者24h、48h、72h及96h止血成功率统计结果均显著高于A组,平均止血时间统计结果同比于A组患者明显更短(P<0.05);药物治疗72h后,B组患者空腹胃酸pH测定值同比于A组患者明显更高(P<0.05);经对两组患者谷丙转氨酶及血肌酐水平加以测定,测定值与治疗前测定值比较无明显变化(P>0.05);经对A组患者药物不良反应发生率加以统计,统计结果为13.33%,与B组患者的10.00%比较不具有统计学差异(P>0.05)。结论 兰索拉唑治疗急性非静脉曲张上消化道出血能够快速提高患者胃内pH值,缩短止血时间,并且不会对患者的肝肾功能产生明显影响,不良反应发生率低,治疗效果明显优于泮托拉唑,具有更高的临床应用价值。Objective To compare the efficacy of Lansoprazole and pantoprazole in the treatment of acute non-varicose upper gastrointestinal bleeding,in order to select a safer and more efficient drug treatment scheme.Methods 60 patients with acute non-varicose upper gastrointestinal bleeding admitted to our hospital from January 2020 to January 2023 were selected as the observation objects,and A prospective controlled trial was designed.The patients were numbered and divided into group A(odd number)and group B(even number)with 30 cases each,pantoprazole and Lansoprazole were given treatment in the two groups.Results The total effective rate of group B was 96.67%,which was significantly higher than 80.00%of group A(P<0.05);The success rate of hemostasis in group B at 24h,48h,72h and 96h was significantly higher than that in group A,and the average hemostasis time was significantly shorter than that in group A(P<0.05).After 72h of drug treatment,fasting gastric acid pH of group B was significantly higher than that of group A(P<0.05);The serum creatinine and propylglutamic transaminase levels of the two groups were measured,and there was no significant change between the measured values and those before treatment(P>0.05).The incidence of adverse drug reactions in group A was 13.33%,which had no significant difference compared with 10.00%in group B(P>0.05).Conclusion Lansoprazole in the treatment of acute non-varicose upper gastrointestinal bleeding can rapidly improve the pH value of the stomach and shorten the hemostasis time,and has no significant impact on the liver and kidney function of the patients.The incidence of adverse reactions is low,and the therapeutic effect is significantly better than pantoprazole,which has higher clinical application value.

关 键 词：兰索拉唑 泮托拉唑 急性非静脉曲张上消化道出血 不良反应 

分 类 号：R573.2[医药卫生—消化系统]