靶向程序性细胞死亡蛋白配体-1多肽类放射性核素标记分子探针研究进展  

Research progress in programmed cell death protein ligand-1 targeting peptide-based radionuclide-labeled molecular probes

作　　者：朱诗宇 梁蓓蓓 付加煜 林建国 邱玲[1,2] ZHU Shiyu;LIANG Beibei;FU Jiayu;LIN Jianguo;QIU Ling(School of Pharmacy,Nanjing Medical University,Nanjing 211166,Jiangsu Province,China;Jiangsu Key Laboratory of Molecular Nuclear Medicine,Jiangsu Institute of Nuclear Medicine,Wuxi 214063,Jiangsu Province,China;School of Basic Medical Sciences,Wenzhou Medical University,Wenzhou 325035,Zhejiang Province,China)

机构地区：[1]南京医科大学药学院,江苏南京211166 [2]江苏省原子医学研究所江苏省分子核医学重点实验室,江苏无锡214063 [3]温州医科大学基础医学院,浙江温州325035

出　　处：《新乡医学院学报》2024年第5期491-496,共6页Journal of Xinxiang Medical University

基　　金：无锡市科技发展资金资助项目(编号:Y20212013)。

摘　　要：程序性细胞死亡蛋白配体-1(PD-L1)是一个重要的免疫检查点分子,在调节机体免疫反应方面发挥重要作用。临床研究表明,肿瘤组织中PD-L1的表达水平与免疫检查点抑制剂疗效密切相关。由于肿瘤的时空异质性,临床上常用的免疫组织化学方法不能全面准确地反映患者体内PD-L1的表达水平,而核医学分子影像技术可在分子水平上无创、实时、动态、可视化监测机体内PD-L1的表达水平。本文主要针对靶向PD-L1多肽类放射性分子探针的研究进行综述,为寻找新型免疫成像的多肽类分子探针及免疫治疗适宜患者的筛选和疗效评估等提供指导。Programmed cell death protein ligand-1(PD-L1)is an important immune checkpoint molecule that plays an important role in regulating the body′s immune response.Several clinical studies have shown that the expression level of PD-L1 in tumors is closely related to the efficacy of immune checkpoint inhibitors.Due to the spatial and temporal heterogeneity of tumors,immunohistochemical methods commonly used in clinical practice cannot accurately and comprehensively reflect the expression level of PD-L1 in patients.Given that nuclear-medicine molecular imaging technology can noninvasively,real-time,dynamically and visually monitor the expression level of PD-L1 in vivo at the molecular level,this article mainly focuses on the research of peptide-based radiolabeled molecular probes targeting PD-L1,with the aim of providing guidance for the search of novel peptide molecular probes for immunoimaging as well as for the screening of immunotherapy-suitable patients and evaluation of therapeutic efficacy,and other clinical applications.

关 键 词：程序性细胞死亡蛋白配体-1 多肽类分子探针 正电子发射型计算机断层显像 单光子发射型计算机断层显像 

分 类 号：R730.51[医药卫生—肿瘤]