山东省抑郁障碍患者生命质量及危险因素  

Quality of life and risk factors of patients with depression in Shandong Province

作　　者：刘俊廷 程小菁[2] 张敬悬[2] 王汝展[2] 李晓靖 王倩[2] 王程辉[3] 丁昊 钱丽菊 万晓娜[6] 田雪 侯宗银 刘风杰 刘进东 LIU Junting;CHENG Xiaojing;ZHANG Jingxuan;WANG Ruzhan;LI Xiaojing;WANG Qian;WANG Chenghui;DING Hao;QIAN Liju;WAN Xiaona;TIAN Xue;HOU Zbngyin;LIU Fengjie;LIU Jindong(Mental Health Collge,Jining Medical University,Jining 272067,Shandong Province,China;Shandong Provincial Mental Health Center,Jinan 250014,China;Weifang Mental Health Center,Weifang 261072,Shandong Province,China;Zibo Mental Health Center,Zibo 255199,Shandong Province,China;Jining Mental Health Center,Jining 272075,Shandong Province,China;Qingdao Mental Health Center,Qingdao 266034,Shandong Province,China;Linyi Mental Health Center,Linyi 276005,Shandong Province,China;Zaozhuang Mental Health Center,Zaozhuang 277103,Shandong Province,China;The Fourth Hospital of Liaocheng,Liaocheng 252002,Shandong Province,China;The Third Hospital of Heze,Heze 274006,Shandong Province,China)

机构地区：[1]济宁医学院精神卫生学院,山东济宁272067 [2]山东省精神卫生中心,济南250014 [3]潍坊市精神卫生中心,山东潍坊261072 [4]淄博市精神卫生中心,山东淄博255199 [5]山东省戴庄医院,山东济宁272075 [6]青岛市精神卫生中心,山东青岛266034 [7]临沂市精神卫生中心,山东临沂276005 [8]枣庄市精神卫生中心,山东枣庄277103 [9]聊城市第四人民医院,山东聊城252002 [10]菏泽市第三人民医院,山东菏泽274006

出　　处：《中国心理卫生杂志》2024年第6期465-472,共8页Chinese Mental Health Journal

基　　金：山东省中西医结合专病防治项目:抑郁障碍防治项目(YXH2019ZXY006)。

摘　　要：目的:研究山东省抑郁障碍患者生命质量特点及相关危险因素。方法:对2015年山东省精神障碍流行病调查中使用精神障碍诊断与统计手册第4版(DSM-Ⅳ)和《DSM-Ⅳ-TR轴I障碍定式临床检查研究版》(SCID-I/P)诊断出的抑郁障碍患者832例和抑郁障碍发病高危人群807例、低危人群819例3组人群,于2020年使用SCID-I/P进行再诊断,并用一般健康问卷(GHQ-12)、简易生命质量问卷、匹兹堡睡眠质量指数量表(PSQI)、儿童期创伤问卷(CTQ)、社会支持评定量表(SSRS)、整体疼痛评估量表(GPS)、蒙特利尔认知评估量表(MoCA)、简易应对方式问卷(SCSQ)进行评估,比较抑郁障碍患者生命质量变化并构建其危险因素模型。结果:抑郁障碍患者基线和5年复评的简易生命质量问卷得分均低于高危组和低危组,抑郁障碍缓解组基线和5年复评的简易生命质量问卷得分均高于未缓解组,高危组和低危组中2020年新发病者基线和5年复评的简易生命质量问卷得分均低于未发病者(均P<0.001)。基线的抑郁障碍诊断、PSQI得分均负向预测5年复评的简易生命质量问卷得分(β=-0.06、-0.15),基线的应对方式倾向正向预测5年复评的简易生命质量问卷得分(β=0.06);基线的简易生命质量问卷得分负向预测5年复评的抑郁障碍诊断、GHQ-12得分及PSQI得分(β=-0.11、-0.17、-0.09),基线的简易生命质量问卷得分正向预测5年复评的应对方式倾向(β=0.13)。5年复评的抑郁障碍诊断、GHQ-12得分、PSQI得分、应对方式倾向、SSRS得分、CTQ得分、GPS得分以及基线的生命质量问卷得分均对5年复评的生命质量问卷得分通过直接或间接途径进行影响。结论:抑郁障碍患者生命质量低于一般人群。抑郁障碍诊断、睡眠质量、心理健康、疼痛、社会支持、儿童期创伤、应对方式等是生命质量的直接和间接危险因素。Objective:To study the life characteristics and related risk factors of patients with depression in Shandong Province.Methods:Based on the 2015 mental epidemiological survey database in Shandong Province,a total of 832 patients with depression,807 high risk individuals with depression,and 819 low-risk individuals were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition(DSM-IV)and the Structured Clinical Interview for DSM-IV-TR Axis I Disorders,Research Version(SCID-I/P).In 2020,SCID-I/P was used for re diagnosis,and the General Health Questionnaire(GHQ-12),Simple Quality of Life question-naire,Pittsburgh sleep quality index(PSQI),Childhood Trauma Questionnaire(CTQ).Social Support Raing Scale(SSRS),Global Pain Scale(GPS),Montreal Cognitive Assessment(MoCA),Simplified Coping Style Question-naire(SCSQ)were used for evaluation.Compare changes in the quality of life of depression patients and construct a risk factor model.Results:Patients with depression had lower scores on the simple quality of life questionnaire at baseline and at retest after 5 years than those in the high-and low-risk groups,those in remission of depression had higher scores on the simple quality of life questionnaire at baseline and at retest after 5 years than those in non-re-mission,and those with new-onset disorder in the high-and low risk groups had lower scores on the simple quality of life questionnaire at baseline and at retest after 5 years han those with no onset disorder(Ps<0.001).Depres-sion diagnosis and PSQI scale scores at baseline negatively predicted at retest after 5 years(β=-0.06,-0.15),.while coping style tendencies at baseline positively predicted(β=0.06).The simple quality of life questionnaire at baseline negatively predicted depression diagnosis at retest after 5 years,GHQ-12 scores at retest after 5 years,and PSQI scale scores t retest after 5 years(β=-0.11,-0.17,-0.09),while the simple quality of life question-naire at baseline positively predicted coping style tendencies at

关 键 词：抑郁障碍 生命质量 危险因素 

分 类 号：R749.41[医药卫生—神经病学与精神病学]