内在情感对癌症发生风险的影响:基于孟德尔随机化研究  

Impact of emotions on cancer risk:a Mendelian randomization study

作　　者：杜钦 朱雨萱 郭一泽 许楠馨 刘棣[1] DU Qin;ZHU Yuxuan;GUO Yize;XU Nanxin;LIU Di(Department of Oncology,The Second Affiliated Hospital of Xi'an Jiaotong University,Xi’an 710004,China)

机构地区：[1]西安交通大学第二附属医院肿瘤科,陕西西安710004

出　　处：《西安交通大学学报（医学版）》2024年第3期376-382,共7页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省重点研发计划项目(2022SF-496);西安交通大学第二附属医院人才基金-科技骨干项目[No.RC(GG201807)];西安交通大学第二附属医院自由探索项目[No.YJ(ZYTS)2019012/No.2020YJ(ZYTS)226];新锐肿瘤支持治疗课题研究项目(No.cphcf-2022-231);医学科研发展基金项目(KM228009)。

摘　　要：目的探究内在情感(幸福感、抑郁情绪、忧虑和内疚感)与癌症(结直肠癌、肝癌、甲状腺癌、肺癌、乳腺癌)的因果关系。方法采用两样本双向孟德尔随机化方法。所有数据基于全基因关联研究(GWAS)汇总数据。逆方差加权法(IVW)得到的结果作为主要结局指标,加权中值法(WM)、MR-Egger法作为补充结果,评价指标为比值比(OR),并进行敏感性分析。结果对于抑郁情绪,提示与肺癌(OR=1.005,95%CI:1.001~1.009,P=0.015)显著相关。对于忧虑,提示与乳腺癌(OR=1.199,95%CI:1.011~1.423,P=0.038)显著相关。对于内疚感,提示与甲状腺癌(OR=2.083,95%CI:1.080~4.017,P=0.029)显著相关。在去除MR-PRESSO检测到的所有潜在多效性SNPs后,忧虑与乳腺癌的关联无统计学差异(P=0.064),忧虑与结直肠癌显著相关(OR=0.739,95%CI:0.571~0.956,P=0.021)。癌症与内在情感之间的关联未发现存在因果关系。结论抑郁情绪与肺癌发生风险增加相关,内疚感与甲状腺癌发生风险增加相关,忧虑可能与结直肠癌发生风险降低相关。Objective To investigate the effects of emotions(subjective well-being,depressed effect,worry,and guilt)on cancer(colorectal cancer,hepatic cancer,thyroid cancer,lung cancer,and breast cancer).Methods Two-sample bi-directional Mendelian randomization(MR)method was adopted.All data were based on summary data from genome-wide association studies(GWAS).Inverse variance weighting(IVW)was used to generate the main results,and weighted median(WM)and MR-Egger methods were employed to calculate supplementary results.The outcome measure was odds ratio(OR),and sensitivity analysis was conducted.Results For depressed effect,a significant association with lung cancer(OR=1.005,95%CI:1.001-1.009,P=0.015)was found.For worry,a significant association with breast cancer(OR=1.199,95%CI:1.011-1.423,P=0.038)was observed.For guilt,a significant association with thyroid cancer(OR=2.083,95%CI:1.080-4.017,P=0.029)was identified.After removing all potentially pleiotropic SNPs detected by MR PRESSO,the association between worry and breast cancer showed no statistical difference(P=0.064),while the association between worry and colorectal cancer remained significant(OR=0.739,95%CI:0.571-0.956,P=0.021).No causal relationship was found between cancer and emotions.Conclusion There is a causal relationship between depression and increased lung cancer incidence,guilt and increased thyroid cancer incidence,as well as anxiety and decreased colorectal cancer incidence.

关 键 词：两样本双向孟德尔随机化 内在情感 癌症 全基因组关联研究 因果效应 

分 类 号：R73[医药卫生—肿瘤]