青少年颈椎间盘突出症有限元模型建立及应力分析  

Establishment and stress analysis of a finite element model for adolescent cervical disc herniation

作　　者：赵宇昕 亮亮 金凤[3] 许阳阳 康志杰 方源 和雨洁 王星 王海燕 李筱贺 Zhao Yuxin;Liang Liang;Jin Feng;Xu Yangyang;Kang Zhijie;Fang Yuan;He Yujie;Wang Xing;Wang Haiyan;Li Xiaohe(Department of Human Anatomy,School of Basic Medicine,Inner Mongolia Medical University,Hohhot 010010,Inner Mongolia Autonomous Region,China;First Clinical Medical College of Inner Mongolia Medical University,Hohhot 010010,Inner Mongolia Autonomous Region,China;Department of Imaging,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010010,Inner Mongolia Autonomous Region,China;Department of Rehabilitation Medicine,Changzhi People’s Hospital,Changzhi 046000,Shanxi Province,China)

机构地区：[1]内蒙古医科大学基础医学院人体解剖教研室,内蒙古自治区呼和浩特市010010 [2]内蒙古医科大学第一临床医学院,内蒙古自治区呼和浩特市010010 [3]内蒙古医科大学附属医院影像科,内蒙古自治区呼和浩特市010010 [4]长治市人民医院康复医学科,山西省长治市046000

出　　处：《中国组织工程研究》2025年第3期448-454,共7页Chinese Journal of Tissue Engineering Research

基　　金：内蒙古自治区自然科学基金项目(2021MS08086),项目负责人:王海燕;2022年度内蒙古自治区卫生健康科技计划项目(202201188),项目负责人:王海燕;内蒙古医科大学2020年度“成果转化”项目(YKD2020CGZH009),项目负责人:王海燕;2021年内蒙古自治区蒙医药协同创新中心科学研究项目(MYYXTYB202104),项目负责人:李筱贺;2021年内蒙古医科大学致远人才项目(ZY0120017),项目负责人:李筱贺;内蒙古医科大学2021年度校级科研重点项目(YKD2021ZD001),项目负责人:李筱贺;内蒙古教育厅高等学校创新团队发展计划(NMGIRT2227),项目负责人:李筱贺;内蒙古自治区2023年自治区重点研发和成果转化计划(科技支撑黄河流域生态保护和高质量发展)项目(2023YFHH0003),项目负责人:李筱贺。

摘　　要：背景:颈椎间盘突出症可引起肩颈部疼痛、上肢放射性疼痛,发病率逐年上升并趋于年轻化,充分了解青少年颈椎生物力学特点,对于延缓青少年颈椎间盘突出症具有重要意义。目的:利用有限元分析技术重建正常青少年及青少年颈椎间盘突出症患者的颈椎模型,分析C_(1)-T_(1)颈椎椎体活动度和纤维环、髓核、终板及小关节软骨的生物力学特征。方法:选择正常青少年和青少年颈椎间盘突出症患者各1例,将连续扫描的颈椎CT原始影像数据以DICOM格式导入Mimics 21.0,分别重建C_(1)-T_(1);随后将建立好的模型导入3-Matic软件进行椎间盘重建,将完善的模型导入Hypermesh软件,对椎体、髓核、纤维环、韧带进行网格划分,生成有效的几何模型,赋予材料属性后将最终模型导入ABAQUS软件中。观察C_(1)-C_(7)各节段颈椎椎体在不同工况下的关节活动度,并分析各节段颈椎纤维环、髓核、终板及小关节软骨的生物力学特征。结果与结论:(1)正常青少年与颈椎间盘突出症青少年患者颈椎模型C1在6种工况下的关节活动度均高于其他椎体,且正常青少年各节段颈椎椎体活动度均大于颈椎间盘突出症青少年患者;(2)正常青少年颈椎模型纤维环及髓核应力最大值在C_(2-3)左侧屈工况(0.43 MPa,0.17 MPa),颈椎间盘突出症青少年患者颈椎模型应力最大值在C_(7)-T_(1)左侧屈工况(0.54 MPa,0.18 MPa);(3)正常青少年颈椎模型终板应力最大值在C_(3)上终板左侧屈工况(1.46 MPa),颈椎间盘突出症青少年患者模型终板应力最大值在C7下终板左侧屈工况(1.32 MPa);(4)正常青少年颈椎小关节软骨应力最大值在C_(2-3)左旋转工况(0.98 MPa),颈椎间盘突出青少年患者的小关节软骨在不同工况下以C_(1-2)应力增加最明显,应力最大在左侧屈(3.50 MPa);(5)提示与正常青少年相比,颈椎间盘突出症青少年患者颈椎曲度改变,颈椎整体关节活动度下降;�BACKGROUND:Cervical disc herniation can cause pain in the neck and shoulder area,as well as radiating pain in the upper limbs.The incidence rate is increasing year by year and tends to affect younger individuals.Fully understanding the biomechanical characteristics of the cervical spine in adolescents is of great significance for preventing and delaying the onset of cervical disc herniation in this age group.OBJECTIVE:To reconstruct cervical spine models for both healthy adolescents and adolescent patients with cervical disc herniation utilizing finite element analysis techniques,to analyze the motion range of the C_(1)-T_(1)cervical vertebrae as well as the biomechanical characteristics of the annulus fibrosus,nucleus pulposus,endplates,and the cartilage of the small joints.METHODS:A normal adolescent’s cervical spine and an adolescent patient with cervical disc herniation were selected in this study.The continuous scan cervical spine CT raw image data were imported into Mimics 21.0 in DICOM format.The C_(1)-T_(1)vertebrae were reconstructed separately.Subsequently,the established models were imported into the 3-Matic software for disc reconstruction.The perfected models were then imported into Hypermesh software for meshing of the vertebrae,nucleus pulposus,annulus fibrosus,and ligaments,creating valid geometric models.After assigning material properties,the final models were imported into ABAQUS software to observe the joint motion range of the C_(1)-C_(7)cervical vertebrae segments under different conditions,and to analyze the biomechanical characteristics of the annulus fibrosus,nucleus pulposus,endplates,and small joint cartilage of each cervical spine segment.RESULTS AND CONCLUSION:(1)In six different conditions,the joint motion range of the C_(1) vertebra in the cervical spine models of both normal adolescent and adolescent patient with cervical disc herniation was higher than that of the other vertebrae.Additionally,the joint motion range of each cervical spine segment in normal adolescent was greater

关 键 词：青少年 颈椎间盘突出症 颈椎应力 有限元分析 生物力学 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R496