1p32缺失在初诊多发性骨髓瘤患者中的预后意义  

The Prognostic Value of Del(1p32)in Patients with Newly Diagnosed Multiple Myeloma

作　　者：郭睿[1] 沈旭星 夏园 金媛媛 李建勇[1] 陈丽娟[1] 仇海荣[1] GUO Rui;SHEN Xu-Xing;XIA Yuan;JIN Yuan-Yuan;LI Jian-Yong;CHEN Li-Juan;QIU Hai-Rong(Department of Hematology,The First Affiliated Hospital of Nanjing Medical University(Jiangsu Province Hospital),Nanjing 210029,Jiangsu Province,China)

机构地区：[1]南京医科大学第一附属医院(江苏省人民医院)血液科,江苏南京210029

出　　处：《中国实验血液学杂志》2024年第3期768-773,共6页Journal of Experimental Hematology

基　　金：国家自然科学基金青年科学基金项目(82200223);江苏省青年自然科学基金(BK20220718)。

摘　　要：目的:分析1p32缺失在初诊多发性骨髓瘤(MM)患者中的预后意义。方法:回顾性分析2017年4月至2022年12月在江苏省人民医院就诊的341例初诊MM患者的临床资料,结合遗传学特征,尤其是1号染色体遗传学异常中的1p32缺失,分析患者的生存及预后。结果:341例初诊MM患者中,1p32缺失阳性患者占7.0%(24/341),伴有1p32缺失的MM患者的无进展生存(PFS)显著短于不伴有1p32缺失患者(P<0.001),总生存(OS)同样更短(P<0.001)。COX风险回归分析显示,1p32缺失是影响MM患者生存的独立危险因素。同时伴有1q21扩增和1p32缺失,即“1号染色体双打击”MM患者的PFS及OS相较于仅有1q21扩增或仅有1p32缺失MM患者更差(PFS:P<0.001;OS:P<0.001)。结论:1p32缺失是影响MM患者PFS及OS的独立危险因素,1p32缺失应广泛应用于初诊MM的预后判断。Objective:To analyze the prognostic value of del(1p32)in patients with newly diagnosed multiple myeloma(MM).Methods:The clinical data of 341 newly diagnosed MM attended in Jiangsu Province Hospital were retrospective analyzed.Clinical characteristic combined with genetic features,especially del(1p32),were analyzed for survival and prognostic of patients.Results:Among the 341 patients with newly diagnosed MM,24(7.0%)patients were del(1p32)positive.The progression-free survival(PFS)and overall survival(OS)were significantly shorter in MM patients with del(1p32)than those without del(1p32)(PFS:P<0.001;OS:P<0.001).The COX proportional-hazards model showed that del(1p32)was an independent risk factor for PFS and OS of patients with MM.The patients with both 1q21 gain/amplification and del(1p32),as"double-hit chromosome 1",have worse prognosis than those with only 1q21 gain/amplification or only del(1p32)(PFS:P<0.001;OS:P<0.001).Conclusion:Del(1p32)is an independent risk factor for PFS and OS of patients with MM.Del(1p32)detection should be widely used in the prognostic analysis for newly diagnosed MM patients.

关 键 词：多发性骨髓瘤 1p32缺失 预后 

分 类 号：R733.3[医药卫生—肿瘤]