STING启动子多态性与多发性骨髓瘤化疗后感染易感性的相关性分析  

Correlation Analysis between STING Promoter Polymorphism and Susceptibility to Infection after Chemotherapy for Multiple Myeloma

作　　者：黄昭萍 杨灿华 HUANG Zhao-Ping;YANG Can-Hua(Department of Hematology,Wuming Hospital Affiliated to Guangxi Medical University,Nanning 530199,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西医科大学附属武鸣医院血液内科,广西南宁530199

出　　处：《中国实验血液学杂志》2024年第3期927-932,共6页Journal of Experimental Hematology

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(Z-A20220780)。

摘　　要：目的:探讨干扰素基因刺激因子(STING)启动子多态性与多发性骨髓瘤化疗后感染易感性的相关性。方法:选取2016年1月至2022年7月由本院收治的102例多发性骨髓瘤化疗患者,根据患者化疗后是否发生感染,分为感染组53例和非感染组49例。分析感染患者的感染部位、病原菌分布特征。比较两组患者STING基因启动子rs587777609位点的基因型分布。分析多发性骨髓瘤化疗后感染的危险因素。结果:感染部位中,消化系统占43.40%,呼吸系统占26.42%,泌尿系统占20.75%,皮肤黏膜占9.43%。感染病原菌中,革兰氏阴性菌占57.14%,革兰氏阳性菌占26.98%,真菌占15.87%。感染组STING基因rs587777609位点的CC基因型频率低于非感染组,TT基因型频率高于非感染组(P<0.05)。感染组合并糖尿病、慢性阻塞性肺疾病、肾功能不全、血清白蛋白<35 g/L、ISS分期Ⅲ期、机械通气、留置导尿的比例均明显高于非感染组(P<0.05)。多因素logistic回归分析显示,合并糖尿病(OR=1.992)、血清白蛋白<35 g/L(OR=2.782)、ISS分期为Ⅲ期(OR=2.707)、机械通气(OR=3.031)、TT基因型(OR=2.401)均是多发性骨髓瘤化疗后感染的危险因素(P<0.05)。结论:STING启动子多态性与多发性骨髓瘤化疗后感染易感性有关,TT基因型患者的感染风险较高。Objective:To investigate the correlation between the stimulator of interferon genes(STING)promoter polymorphism and the susceptibility to infection after chemotherapy for multiple myeloma.Methods:A total of 102 patients who had undergone chemotherapy for multiple myeloma in our hospital from January 2016 to July 2022 were selected.Depending on the presence or absence of infection after chemotherapy,the enrolled patients were divided into infection group(53 cases)and non-infection group(49 cases).The infection sites and distribution characteristics of pathogenic bacteria of the infection group were analyzed.The genotype distribution of STING gene promoter rs587777609 was compared between the two groups,and the risk factors of infection after chemotherapy for multiple myeloma were analyzed.Results:For infection site,digestive system,respiratory system,urinary system,skin and mucous membranes accounted for 43.40%,26.42%,20.75%,and 9.43%,respectively.For pathogenic bacteria,Gram-negative bacteria,Gram-positive bacteria and fungi accounted for 57.14%,26.98%,and 15.87%,respectively.The CC genotype frequency of STING gene rs587777609 locus in the infection group was lower than that in the non-infection group,while the TT genotype frequency was higher than that in the non-infection group(P<0.05).The proportions of patients with diabetes,chronic obstructive pulmonary disease,renal insufficiency,serum albumin level<35 g/L,ISS stage III,mechanical ventilation,and indwelling catheter in the infection group were higher than those in the non-infection group(P<0.05).Multivariate logistic regression analysis showed that diabetes(OR=1.992),serum albumin level<35 g/L(OR=2.782),ISS stage III(OR=2.707),mechanical ventilation(OR=3.031),and TT genotype(OR=2.401)were risk factors of infection after chemotherapy for multiple myeloma(P<0.05).Conclusion:There is a correlation between STING promoter polymorphism and the susceptibility to infection after chemotherapy for multiple myeloma,and patients with TT genotype have a higher risk of i

关 键 词：多发性骨髓瘤 干扰素基因刺激因子 启动子 基因多态性 化疗 感染 

分 类 号：R733.3[医药卫生—肿瘤]