长链非编码RNA在急性髓细胞白血病发生发展中作用的研究进展  

Research Progress on Role of Long Non-Coding RNA in Occurrence and Development of Acute Myeloid Leukemia--Review

作　　者：卢晓诗 王薪祺 杜英男 张继红[2] LU Xiao-Shi;WANG Xin-Qi;DU Ying-Nan;ZHANG Ji-Hong(The Fourth Clinical College,China Medical University,Shenyang 110122,Liaoning Province,China;Hematology Laboratory,Shengjing Hospital of China Medical University,Shenyang 110004,Liaoning Province,China)

机构地区：[1]中国医科大学第四临床学院,辽宁沈阳110122 [2]中国医科大学附属盛京医院血液研究室,辽宁沈阳110004

出　　处：《中国实验血液学杂志》2024年第3期974-978,共5页Journal of Experimental Hematology

基　　金：国家自然科学基金青年基金(8220027);国家自然科学基金(82070165)。

摘　　要：近年来,长链非编码RNA(lnc RNA)在急性髓细胞白血病(AML)中的重要性引起人们的广泛关注,其中发挥促癌作用的lnc RNA主要有HOTAIR、UCA1、H19、ITGB2-AS1和SNHG家族的部分基因,而起抑癌作用的lnc RNA主要有H22954、NEAT1、SNHG4、LINC01128等。本文就lnc RNA在AML发生发展中的作用以及与AML耐药和预后判断相关的lncRNA进行综述,以期为AML的诊断和预后分析提供理论依据。In recent years,the importance of long non-coding RNA(lncRNA)in acute myeloid leukemia(AML)has attracted wide attention.Among them,lncRNAs that play a role in promoting cancer mainly include HOTAIR,UCA1,H19,ITGB2-AS1 and some genes of SNHG family,while in tumor suppression mainly include H22954,NEAT1,SNHG4,LINC01128,etc.This article reviews the role of lncRNAs in the occurrence and development of AML,as well as those related to AML resistance and prognosis assessment,so as to provide a theoretical basis for the diagnosis and prognosis analysis of AML.

关 键 词：急性髓细胞白血病 长链非编码RNA 促癌 抑癌 耐药 预后 

分 类 号：R733.71[医药卫生—肿瘤]