中老年人不同部位脑微出血的相关危险因素分析  

Risk Factors Analysis of Cerebral Microbleeds in Different Regions on Middle⁃aged and Elderly People

作　　者：鲁恒检 林心柔 李晨光 潘经锐[1] 王鸿轩[1] 彭英[1] LU Heng-jian;LIN Xin-rou;LI Chen-guang;PAN Jing-rui;WANG Hong-xuan;PENG Ying(Department of Neurology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,510120)

机构地区：[1]中山大学孙逸仙纪念医院神经科,510120

出　　处：《岭南急诊医学杂志》2024年第2期96-100,共5页Lingnan Journal of Emergency Medicine

基　　金：国家重点研发项目(2018YFC1314400,2018YFC1314401);中德合作交流项目(M0746)。

摘　　要：目的:研究中老年患者不同部位脑微出血(CMBs)的相关危险因素。方法:通过中山大学孙逸仙纪念医院医学大数据平台收集自2022年1月至2023年5月的住院患者共669例患者,先分成CMBs阳性组(123例)和CMBs阴性组(546例),再将CMBs阳性组细分成仅脑叶组、仅深部组和广泛组三个亚组,分别通过对比任意的CMBs阳性亚组与CMBs阴性组的病史资料和实验室检查结果进行单因素分析。再采用Logistics回归分析各个脑微出血亚组的独立危险因素。结果:在单因素分析中筛选出了一些备选的危险因素,后纳入Logistics回归分析,结果显示,饮酒、高血压、MCV、HbA1C、Hb是脑微出血的独立危险因素,因不同亚组有所不同。结论:脑微出血的相关危险因素较多,且因分布部位而异,戒酒、控制血压、控糖将可能对脑微出血有重要预防和治疗价值。Objective:To study the relevant risk factors of cerebral microbleeds(CMBs)in different parts of mid⁃dle⁃aged and elderly patients.Methods:A total of 669 hospitalized patients from Jan 2022 to May 2023 were collected through the medical big data platform of Sun Yat⁃sen Memorial Hospital of Sun Yat⁃sen University.They were first divid⁃ed into a CMBs positive group(123 cases)and a CMBs negative group(546 cases).Then,the CMBs positive group was subdivided into three subgroups:lobar only,deep only,and extensive one and perform univariate analysis by com⁃paring medical history data and laboratory tests results between any CMBs positive subgroup and CMBs negative group.Then,a logistic regression model was used to analyze the independent risk factors of each subgroup of cerebral micro⁃bleeds.Results:In the univariate analysis,some alternative risk factors were selected and included in the logistic regres⁃sion analysis.The results showed that alcohol consumption,hypertension,MCV,HbA1C,and Hb were independent risk factors for CMBs,which varied among different subgroups.Conclusion:There are many risk factors related to CMBs,and they vary depending on the distribution location.Abstinence from alcohol,controlling blood pressure,and controlling sugar may have important preventive and therapeutic value for CMBs.

关 键 词：脑微出血 中老年人 分布 危险因素 LOGISTIC回归分析 

分 类 号：R743.34[医药卫生—神经病学与精神病学]