颅脑MRI和肛门括约肌肌电图联合α-突触核蛋白在帕金森病和多系统萎缩P型患者中的应用  

Application of cranial MRI,anal sphincter electromyography combined withα-synuclein in patients with Parkinson's disease and patients with multiple system atrophy-parkinsonian type

作　　者：黄颖 林敬源 HUANG Ying;LIN Jingyuan(Department of Neurology,Fujian Provincial Geriatric Hospital,Fuzhou(350000),Fujian,China)

机构地区：[1]福建省老年医院神经内科,福建福州350000

出　　处：《癫痫与神经电生理学杂志》2024年第2期82-86,共5页Journal of Epileptology and Electroneurophysiology(China)

摘　　要：目的探讨颅脑MRI、肛门括约肌肌电图联合唾液α-突触核蛋白(α-syn)水平在帕金森病(PD)和多系统萎缩P型(MSA-P)患者中的鉴别诊断价值。方法选取2016年9月至2023年6月福建省老年医院收治的142例患者,其中81例PD患者作为PD组、41例MSA-P患者作为MSA-P组,比较两组患者在颅脑MRI壳核裂隙征、肛门括约肌肌电图的卫星电位及唾液α-syn水平上的差异。结果MSA-P组患者壳核裂隙征和卫星电位的出现率显著高于PD组,唾液α-syn水平也明显高于PD组。多元回归和ROC曲线分析显示,壳核裂隙征、唾液的α-syn水平及卫星电位的联合应用可鉴别PD和MSA-P患者。结论联合应用颅脑MRI、肛门括约肌肌电图及唾液α-syn可以有效地鉴别PD和MSA-P型,为临床诊断提供重要的辅助手段。Objective To explore the diagnostic values of cranial MRI,anal sphincter electromyography(AS-EMG)combined salivaryα-synuclein(α-syn)level in patients with Parkinson's disease(PD)and patients with multiple system atrophy-parkinsonian type(MSA-P).Methods A total of 142 patients admitted to Fujian Provincial Geriatric Hospital from September 2016 to June 2023 were selected,among which,81 patients with PD were selected as PD group,and 41 with MSA-P patients as MSA-P group.Putaminal slit in Cranial MRI,satellite potential in AS-EMG and salivaryα-syn level were compared between two groups.Results The incidences of putaminal slit and satellite potential in MSA-P group were significantly higher than those in PD group,andα-syn level was also significantly higher than that of PD group.Multiple regression and ROC curve analyses showed that the combined application of putaminal slit,salivaryα-syn and satellite potential may differentiate the patients with PD and the patients with MSA-P.Conclusion Combined application of cranial MRI,AS-EMG and salivaryα-syn level can effectively distinguish between PD and MSA-P types,providing important auxiliary means for clinical diagnosis.

关 键 词：帕金森病 多系统萎缩 肛门括约肌肌电图 Α-突触核蛋白 

分 类 号：R741.044[医药卫生—神经病学与精神病学] R742.5[医药卫生—临床医学]