复合水杨酸凝胶的制备与研究  

Preparation and study of a composite salicylic acid gel

作　　者：范玲玲 吴恙 任环宇 FAN Ling-ling;WU Yang;REN Huan-yu(Late-Night Skin Research Laboratory(Shanghai)Co.,Ltd.,Shanghai 200000,China)

机构地区：[1]熬夜肌实验室系统工程(上海)有限公司,上海200000

出　　处：《日用化学品科学》2024年第5期26-29,39,共5页Detergent & Cosmetics

摘　　要：为了解决水杨酸在护肤品配方中刺激性问题,以水杨酸、甲氧基水杨酸钾和辛酰水杨酸作为功效组合物,通过特定工艺制备了一款复合水杨酸凝胶。与等摩尔单一水杨酸凝胶及行业内常用的泊洛沙姆水杨酸凝胶进行温和性、去角质功效和抑菌功效对比研究。结果显示,复合水杨酸凝胶与等摩尔单一水杨酸凝胶对比,其斑马鱼自旋抑制率高达147%,具有显著的舒缓功效,等摩尔单一水杨酸凝胶斑马鱼100%死亡,具有很强的刺激性,复合水杨酸凝胶去角质功效提升7.34%,两者抑菌功效相当;复合水杨酸凝胶与泊洛沙姆水杨酸凝胶对比,其温和性提升40%,去角质功效提升23.83%,两者抑菌功效相当。研究表明复合水杨酸凝胶可以改善水杨酸配方的刺激性,且具有较强的去角质和抑菌功效。In order to solve the irritating problem of salicylic acid in the formula of skincare products,a composite salicylic acid gel was prepared with salicylic acid,potassium methoxysalicylic acid and caprylyl salicylic acid as effective compositions by special process.The gentleness,exfoliating effect and antibacterial effect were compared with the equimolar salicylic acid gel and poloxham salicylic acid gel commonly used in industry.The results showed that compared with the isomolar single salicylic acid gel,the zebrafish spin inhibition rate was as high as 147%,with significant soothing effect.The isomolar single salicylic acid gel caused 100%death of zebrafish,with strong irritation.The exfoliating effect of the composite salicylic acid gel increased by 7.34%,and the antibacterial effect of the two was comparable.Compared with the poloxam salicylic acid gel,the compound salicylic acid gel increased its gentleness by 40%and the exfoliating effect by 23.83%,and the antibacterial effect of both was similar.The results show that the compound salicylic acid gel can improve the irritation of the salicylic acid formula,and has strong exfoliating and antibacterial effects.

关 键 词：复合水杨酸 温和 去角质 抑菌 

分 类 号：TQ658[化学工程—精细化工]