基于体素分析的首发青少年抑郁症全脑DTI研究  

A voxel-based DTI study of whole-brain in adolescents with first-episode depressive disorder

作　　者：邓杰 何建波 汪雨婷 袁义志 隆晓菁[5] 郭鑫 杨虹莉 冯莉 周玉 邱丽华[3,6] DENG Jie;HE Jian-bo;WANG Yu-ting(Department of Radiology,the Fourth People’s Hospital of Yibin,Sichuan 644000,China)

机构地区：[1]宜宾市第四人民医院放射科,四川644000 [2]西南医科大学附属医院放射科,四川646000 [3]宜宾市第二人民医院医学影像中心,四川644000 [4]宜宾市第二人民医院心理卫生科,四川644000 [5]中国科学院深圳先进技术研究院,广东518055 [6]宜宾市第二人民医院临床医学研究与转化中心,神经影像大数据研究中心,四川644000

出　　处：《放射学实践》2024年第5期611-616,共6页Radiologic Practice

基　　金：四川省科技计划项目(2018JY0666);功能与分子影像四川省重点实验室开放课题(SCU-HM-2021001);宜宾市卫生健康委员会项目(2020YW085);成都中医药大学“杏林学者”课题(YYZX2020111)。

摘　　要：目的:运用磁共振弥散张量成像(DTI)技术探讨首发未治疗青少年抑郁症患者的脑白质微结构变化特点。方法:前瞻性纳入35例首发未治疗青少年抑郁症患者(抑郁症组)和年龄、性别及受教育程度相匹配的26例健康志愿者(对照组)进行DTI扫描,运用FSL软件计算全脑白质各向异性分数(FA),应用基于体素分析(VBA)方法比较两组间全脑白质FA差异,并分析抑郁症组脑白质微结构改变与临床数据的相关性。结果:抑郁症组17项汉密尔顿抑郁量表(HAMD-17)评分高于对照组(P<0.01)。与对照组相比,抑郁症组脑桥、左侧小脑前叶白质FA值升高(簇水平P<0.05,FWE校正),未发现白质FA值减低的脑区;脑桥FA值与HAMD-17评分呈负相关(r=-0.352,P=0.038)。结论:青少年抑郁症患者脑桥小脑环路受损,在疾病早期出现脑白质FA值升高,可能是神经纤维代偿性再生所致。Objective:This study aims to explore the characteristics of white matter microstructure in adolescents with first-episode untreated depressive disorder by magnetic resonance diffusion tensor imaging(DTI).Methods:A total of 35 adolescents with first-episode untreated depressive disorder(depression group)and 26 healthy volunteers matched for age,gender,and education level(control group)underwent DTI scanning.The whole-brain white matter fractional anisotropy(FA)was calculated using FSL software.Voxel-based analysis(VBA)method was used to compare the difference of whole-brain white matter FA between the two groups,and the correlation between the changes of white matter microstructure and clinical data was analyzed in the depression group.Results:The Hamilton Depression Rating Scale-17(HAMD-17)scores in the depression group was higher than those in the control group(P<0.01).Compared to the control group,the depression group showed increased FA values in the pontine and left cerebellar anterior lobe white matter(cluster-level P<0.05,FWE corrected),with no brain regions exhibiting decreased FA values.The FA value of the pontine region was negatively correlated with the HAMD-17 score(r=-0.352,P=0.038)in the depression group.Conclusions:The pontocerebellar circuit is impaired in adolescents with first-episode untreated depressive disorder.The increased FA value of the white matter in the early stage of the disease may be caused by compensatory regeneration of nerve fibers.

关 键 词：青少年 抑郁症 弥散张量成像 白质 磁共振成像 各向异性分数 

分 类 号：R7494[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]