血清AREG水平及CT定量参数与直肠癌脉管侵犯、淋巴结转移的相关性及预测价值研究  

Correlation and predictive value of serum AREG levels and CT quantitative parameters with vascular invasion and lymph node metastasis in rectal cancer

作　　者：徐林生[1] 徐翔[2] 杨金凤[3] 胡良先 胡炳德[1] XU Lin-sheng;XU Xiang;YANG Jin-feng(Department of Digestive Medicine,Navy Anqing Hospital,Anhui 246004,China)

机构地区：[1]海军安庆医院消化内科,安徽246004 [2]海军安庆医院影像中心,安徽246004 [3]海军安庆医院病理科,安徽246004

出　　处：《放射学实践》2024年第5期652-657,共6页Radiologic Practice

摘　　要：目的:探讨血清外周血双调蛋白(AREG)水平及CT定量参数与直肠癌脉管侵犯、淋巴结转移的相关性及预测价值。方法:回顾性分析我院87例直肠癌患者的临床及影像资料,根据病理结果是否发生脉管侵犯与淋巴结转移进行分组,分别为脉管侵犯阳性(A组)与阴性(B组),淋巴结转移阳性(C组)与阴性(D组)。对比各组患者血清AREG浓度水平、CT定量参数,分析以上指标与脉管侵犯、淋巴结转移的相关性。结果:病理结果显示87例患者中32例为直肠癌脉管侵犯阳性,55例脉管侵犯阴性;46例淋巴结转移阳性,41例淋巴结转移阴性。t检验与Logistic回归模型分析结果显示,血清AREG水平、静脉期无水碘密度、静脉期Eff-Z值与直肠癌脉管侵犯相关,血清AREG水平、静脉期Eff-Z值与淋巴结转移相关。血清AREG水平、静脉期无水碘密度值、静脉期Eff-Z值及三者联合预测脉管侵犯的AUC分别为0.772、0.784、0.738、0.901,血清AREG水平、静脉期Eff-Z值、两者联合预测淋巴结转移的AUC分别为0.707、0.709、0.716。结论:血清AREG水平及CT定量参数中静脉期无水碘密度值、静脉期Eff-Z值与直肠癌脉管侵犯相关,血清AREG水平、CT定量参数中静脉期Eff-Z值与淋巴结转移相关。血清AREG水平及CT定量参数对预测直肠癌脉管侵犯、淋巴结转移具有一定价值。Objective:To investigate the correlation and predictive value of serum AREG levels and CT quantitative parameters with vascular invasion and lymph node metastasis in rectal cancer.Methods:The clinical and imaging data of 87 patients with rectal cancer in our hospital were retrospectively analyzed.The patients were divided into two groups based on the presence of vascular invasion and lymph node metastasis,namely positive(Group A)and negative(Group B)for vascular invasion,and positive(Group C)and negative(Group D)for lymph node metastasis.The serum AREG concentration levels and CT quantitative parameters were compared among the groups,and the correlation between these indicators and vascular invasion and lymph node metastasis was analyzed.Results:Pathological analysis showed that among the 87 patients,32 had positive vascular invasion and 55 had negative vascular invasion;46 had positive lymph node metastasis and 41 had negative lymph node metastasis.The results of t-test and logistic regression analysis showed that serum AREG levels,venous phase non-water iodine density and venous phase Eff-Z value were associated with vascular invasion in patients with rectal cancer,while serum AREG levels and venous phase Eff-Z value were associated with lymph node metastasis.The AUC values for predicting vascular invasion in patients using serum AREG levels,venous phase non-water iodine density,venous phase Eff-Z value and their combination were 0.772,0.784,0.738 and 0.901,respectively.The AUC values for predicting lymph node metastasis in patients using serum AREG levels,venous phase Eff-Z value and their combination were 0.707,0.709 and 0.716,respectively.Conclusion:Serum AREG levels and CT quantitative parameters,including venous phase non-water iodine density and venous phase Eff-Z value,are associated with vascular invasion in rectal cancer,while serum AREG levels and venous phase Eff-Z value are associated with lymph node metastasis.Serum AREG levels and CT quantitative parameters have certain predictive value for vascul

关 键 词：直肠癌 外周血双调蛋白 体层摄影术 X线计算机 脉管侵犯 淋巴结转移 

分 类 号：R735.3[医药卫生—肿瘤] R814.42[医药卫生—临床医学]