乌司他丁对腹腔镜结直肠癌根治术患者术后免疫功能的影响研究  

Study on effect of ulinastatin on postoperative immune function in patients undergoing laparoscopic radical resection for colorectal cancer

作　　者：金鑫 刘文广 张颖 甘蕾蕾 JIN Xin;LIU Wen-guang;ZHANG Ying(Zaozhuang Hospital of Traditional Chinese Medicine,Zaozhuang 277000,China)

机构地区：[1]枣庄市中医医院外三科,277000 [2]枣庄市中医医院手术室

出　　处：《中国实用医药》2024年第8期125-127,共3页China Practical Medicine

摘　　要：目的探讨乌司他丁对腹腔镜结直肠癌根治术患者术后免疫功能的影响。方法80例行腹腔镜结直肠癌根治术治疗的结直肠癌患者作为研究对象,以投掷硬币法作为治疗研究分组依据,分为参照组及研究组,各40例。其中,参照组术前未施以任何药物治疗,研究组术前施以乌司他丁治疗。比较两组患者CD3^(+)、CD3^(+)CD8^(+)、CD3^(+)CD4^(+)、CD4/CD8水平及术后并发症总发生率。结果研究组患者CD3^(+)(72.25±2.52)%、CD3^(+)CD8^(+)(19.58±2.52)%、CD3^(+)CD4^(+)(50.25±2.52)%、CD4/CD8(2.58±0.25)同参照组的(45.39±2.52)%、(13.29±1.27)%、(20.25±3.12)%、(0.52±0.13)比较显著提升(P<0.05)。研究组40例患者中,发生感染患者1例,发生出血患者1例,总并发症为2例(5.00%);参照组40例患者中,发生感染患者2例,发生出血患者2例,总并发症为4例(10.00%);研究组患者术后并发症总发生率同参照组比较,结果未呈现出明显差异(P>0.05)。结论行腹腔镜结直肠癌根治术治疗的结直肠癌患者术前应用乌司他丁,可将患者CD3^(+)、CD3^(+)CD8^(+)、CD3^(+)CD4^(+)、CD4/CD8水平显著提高,并且不会导致术后感染、出血的增加,可促进患者预后恢复。Objective To explore the effect of ulinastatin on postoperative immune function in patients undergoing laparoscopic radical resection for colorectal cancer.Methods 80 patients with colorectal cancer who underwent laparoscopic radical resection for colorectal cancer were selected as the study subjects,and they were divided into a reference group and a study group according to the coin-tossing method,with 40 cases in each group.The reference group did not receive any drug treatment before surgery,and the study group received ulinastatin treatment before surgery.The CD3^(+),CD3^(+)CD8^(+),CD3^(+)CD4^(+),CD4/CD8 and total incidence of postoperative complications were compared between the two groups.Results+The study group had CD3 of(72.25±2.52)%,CD3^(+)CD8^(+)of(19.58±2.52)%,CD3^(+)CD4^(+)of(50.25±2.52)%,and CD4/CD8 of(2.58±0.25),which were significantly higher than(45.39±2.52)%,(13.29±1.27)%,(20.25±3.12)%,and(0.52±0.13)in the reference group(P<0.05).Among the 40 patients in the study group,1 case had infection and 1 case had hemorrhage,and the total number of complications was 2 cases(5.00%).Among the 40 patients in the reference group,2 cases had infection and 2 cases had hemorrhage,and the total number of complications was 4 cases(10.00%).The total incidence of postoperative complications in the study group was not significantly different from that in the reference group(P>0.05).Conclusion The preoperative application of ulinastatin in patients undergoing laparoscopic radical surgery for colorectal cancer can significantly increase their levels of CD3^(+),CD3^(+)CD8^(+),CD3^(+)CD4^(+),and CD4/CD8,without causing an increase in postoperative infection and bleeding,which can promote patients'prognostic recovery.

关 键 词：乌司他丁 腹腔镜结直肠癌根治术 结直肠癌 免疫功能 

分 类 号：R735.34[医药卫生—肿瘤]