青少年特发性脊柱侧凸进展风险的表观遗传学因素研究进展  

Research progress on epigenetic factors for adolescent idiopathicscoliosis progression risk

作　　者：刘小梅[1] 王艳洋 刘敏[1] 王谦[1] LIU Xiaomei;WANG Yanyang;LIU Min;WANG Qian(Department of Rehabilitation Medical Center,West China Hospital of Sichuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]四川大学华西医院康复医学中心,成都610041

出　　处：《重庆医学》2024年第9期1401-1405,1411,共6页Chongqing medicine

基　　金：四川省康复辅具适配中心项目(TJCZCJJK001)。

摘　　要：青少年特发性脊柱侧凸(AIS)是一种高度异质性疾病,一部分患者呈现明显的进行性加重,一部分患者则相对稳定。准确识别进展高风险患者有助于早期干预治疗,控制侧凸进展,并避免进展低风险患者的过度医疗。表观遗传学因素可动态调控基因的表达,不改变基因序列,充分反映遗传及环境的相互作用,在预测AIS的进展方面拥有巨大潜力。最近的研究报道了众多与AIS进展相关的表观遗传学因素,这些因素在AIS进展预测上显示出积极作用。该文对AIS进展风险的表观遗传学因素的研究进展进行综诉,期望为后续AIS的治疗及研究提供思路。Adolescent idiopathic scoliosis(AIS)is a highly heterogeneous condition,with some patients showing marked progressive exacerbation and others relatively stable.Accurate identification of patients at high risk of progression can help to intervene early in treatment to control scoliosis progression and avoid over medication of patients at low risk of progression.Epigenetic factors dynamically regulate gene expression without altering the gene sequence,fully reflecting genetic and environmental interactions,and hold great potential in predicting AIS progression.Recent studies have reported numerous epigenetic factors associated with AIS progression and have shown positive results in the prediction of AIS progression.This article provides an overview of research progress on epigenetic factors at risk for AIS progression,with the expectation that it will provide ideas for subsequent AIS treatment and research.

关 键 词：青少年 特发性脊柱侧凸 表观遗传学 进展风险 综述 

分 类 号：R682.3[医药卫生—骨科学]