肝内胆管癌的多组学研究进展  

Research progress on the multi-omics of intrahepatic cholangiocarcinoma

作　　者：康美清 吴忠均[1] 廖锐[1] Kang Meiqing;Wu Zhongjun;Liao Rui(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院肝胆外科,重庆400016

出　　处：《中华肝胆外科杂志》2024年第4期312-317,共6页Chinese Journal of Hepatobiliary Surgery

基　　金：国家自然科学基金(82170666);重庆市自然科学基金(CSTB2022NSCQ-MSX0112);重庆医科大学未来医学青年创新团队(W0087)。

摘　　要：肝内胆管癌(ICC)是肝内第二常见的原发恶性肿瘤,起病隐匿,病死率高。近年来高通量测序技术被广泛应用于ICC的多组学研究,不仅发现了许多新的致病机制,还为ICC的分层分型、预后评估以及临床综合治疗提供了依据。本文综述ICC在基因组学、表观组学、转录组学、蛋白质组学、代谢组学、单细胞测序组学及整合组学中的研究进展,为ICC的临床诊疗提供参考。Intrahepatic cholangiocarcinoma(ICC)is the second most common primary neoplasm in the liver,with insidious clinical symptoms and high mortality rate.In recent years,high-throughput sequencing technologies have been widely used in the multi-omics research of ICC,which not only promote the discovery of some new pathogenic mechanisms,but also provide a profound basis for the stratified classification,prognosis assessment and clinical comprehensive treatment strategy of this lethal tumor.This review focuses on the progress of ICC in genomics,epigenomics,transcriptomics,proteomics,metabolomics,single-cell sequencing omics and integrative omics,and provides ideas for the diagnosis and treatment of this tumor.

关 键 词：胆管上皮癌 多组学研究 肿瘤微环境 分子表型 

分 类 号：R735.7[医药卫生—肿瘤]